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Hyperviscosity / thick blood
Hyperviscosity / thick blood -- Posted by doe on 06-13-04 14:52
Semin Thromb Hemost. 2003 Oct;29(5):459-65. Related Articles, Links
Hyperviscosity as a complication in a variety of disorders.
Rampling MW.
Imperial College School of Medicine, South Kensington, London, United Kingdom.
m.rampling@imperial.ac.uk
For a considerable time, hyperviscosity syndrome has been widely recognized as
a serious manifestation of polycythemia and plasma cell dyscrasia. In this
article a number of conditions will be considered in which the association with
hyperviscosity has been more recently recognized and is less widely known.
These conditions are hyperleukocytosis, retinoic acid therapy, and connective
tissue disease such as rheumatoid arthritis. The essential problems in the
first two are the hugely elevated white cell count (WCC) and the mechanical
properties of the leukocytes, in other words, their relatively poor
deformability and their adhesiveness for the endothelium. In the last, the
essential problem is hugely elevated plasma viscosity due to immunocomplexes.
They lead to increased flow resistance, especially in the microvessels,
abnormal flow, and significant clinical symptoms. The details of the causes of
the hyperviscosity, the symptoms that result, and the forms of treatment are
discussed.
PMID: 14631545 [PubMed - in process]
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