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--- Drug makes "smart" assault on arthritis
Thank you Katherine and yes,,, the future is now. Harv "Katherine Wolfe" news:cb349j02rk1@enews1.newsguy.com... > > I read this article on cnn.com, and thought of you guys. Looks like there > will be a new class of rheumatoid arthritis drugs coming along..... > > Katherine > > ==================================== > > http://www.cnn.com/2004/HEALTH/conditions/06/18/arthritis.drug.ap/index.html > > Drug makes 'smart' assault on arthritis > > BOSTON, Massachusetts (AP) -- For the first time, a drug has relieved > rheumatoid arthritis by knocking out a certain type of immune cell -- an > approach that could open the way for precisely targeted, "smart" treatments > for the joint disease and other illnesses, too. > > Other arthritis drugs on the market either treat just the symptoms, or > employ a broader, more scattershot effect against the underlying process. > Such drugs can have toxic side effects because they kill healthy cells along > with the diseased ones. > > The latest research, an international study led at University College London > and published in Thursday's New England Journal of Medicine, looked at a > drug called rituximab, and the results were promising. > > "I think this is a pivotal study," said Dr. John Klippel, president of the > Arthritis Foundation. "This is opening up a new era of targeted biologic > therapies for rheumatoid arthritis." > > In rheumatoid arthritis, antibodies misdirect friendly fire against the > body's own joint linings. Joints become inflamed, swollen and painful. More > than 2 million Americans, mostly women, have the disease. > > Rituximab, which is sold under the brand name Rituxan and is already > approved for non-Hodgkin's lymphoma, targets B cells, which manufacture > these antibodies. > > The researchers compared rituximab to other drugs in 161 patients with > arthritis. > > For two weeks, patients took rituximab alone or in combination with two > other drugs: the standard drug, methotrexate, and the less widely used > cyclophosphamide. Another group took methotrexate alone. Roche, a > distributor of rituximab, funded and participated in the study. > > After six months, more than 40 percent of patients who took rituximab > combinations were greatly improved. One-third of patients on rituximab alone > were greatly improved. But only 13 percent of those on the standard drug > alone improved that much. > > "One of the things that is truly unique is that a very short course ... > appears to have a very long-lasting effect," Klippel said. > > Some doctors, including the study's authors, said rituximab needs more > testing before any widespread use. They said other B-cell-killing drugs are > under development and could eventually outperform rituximab. > > Researchers are also testing similar targeted approaches against lupus, > multiple sclerosis and other autoimmune diseases. > > Both methotrexate and cyclophosphamide are sometimes employed as > chemotherapy drugs and attack a broader range of tissue than rituximab. The > newer drug kills close to 90 percent of B cells, which the body then > replenishes with healthy new ones. > > Rituximab is one of the most narrowly aimed and efficient members in the > modern family of targeted drugs that include the breast cancer treatment > Herceptin. > > Of all the tested treatments for rheumatoid arthritis, "it goes closest to > the root of the disease," said the study's lead author, Dr. Jonathan Edwards > of University College London. > > However, the drug could pose a danger of chest infection, especially if > given repeatedly, Edwards said. One rituximab patient in the study died of > pneumonia, though it was not clear if the drug was responsible. > >
Guys, when chemistry is involved is not good. Arthritis is generated by an over-active immune system, this means that the body attacks itself. I suffered terrible pain as well. My left hip and ankle were very stiff and when it was to step upstairs always I was bending only the right leg and the exercise was still very painful. I've tried many medicines and nutritional supplements including the ones I consider the best in the world (Reliv) but the enhancements were always minor and not lasting. But my research paid off: I discovered the best for my condition, namely the best immune system moderator in the world: this is called Transfer Factor in combination with a strong anti-oxidant (Choice 50). Well, in only 2 weeks my pain disappeared and in one month my joints were as in my youth (I am 60 now). Due to the spectacular results I joined the distribution network for such miracle products. I am really sorry to tell you about the business when you suffer atrocious pain, but this is only my excuse coming from the bottom of my heart for being obliged to send you to the sites where you could find best information. These are: http://www.4-life.com http://www.wellnesswatch.net and the last one from where you could buy these products (please consider the above excuses) is: http://www.my4life.com/choice I hope you'll find this piece of info useful. Regards, Michael Balutescu "Katherine Wolfe" news:cb349j02rk1@enews1.newsguy.com... > > I read this article on cnn.com, and thought of you guys. Looks like there > will be a new class of rheumatoid arthritis drugs coming along..... > > Katherine > > ==================================== > > http://www.cnn.com/2004/HEALTH/conditions/06/18/arthritis.drug.ap/index.html > > Drug makes 'smart' assault on arthritis > > BOSTON, Massachusetts (AP) -- For the first time, a drug has relieved > rheumatoid arthritis by knocking out a certain type of immune cell -- an > approach that could open the way for precisely targeted, "smart" treatments > for the joint disease and other illnesses, too. > > Other arthritis drugs on the market either treat just the symptoms, or > employ a broader, more scattershot effect against the underlying process. > Such drugs can have toxic side effects because they kill healthy cells along > with the diseased ones. > > The latest research, an international study led at University College London > and published in Thursday's New England Journal of Medicine, looked at a > drug called rituximab, and the results were promising. > > "I think this is a pivotal study," said Dr. John Klippel, president of the > Arthritis Foundation. "This is opening up a new era of targeted biologic > therapies for rheumatoid arthritis." > > In rheumatoid arthritis, antibodies misdirect friendly fire against the > body's own joint linings. Joints become inflamed, swollen and painful. More > than 2 million Americans, mostly women, have the disease. > > Rituximab, which is sold under the brand name Rituxan and is already > approved for non-Hodgkin's lymphoma, targets B cells, which manufacture > these antibodies. > > The researchers compared rituximab to other drugs in 161 patients with > arthritis. > > For two weeks, patients took rituximab alone or in combination with two > other drugs: the standard drug, methotrexate, and the less widely used > cyclophosphamide. Another group took methotrexate alone. Roche, a > distributor of rituximab, funded and participated in the study. > > After six months, more than 40 percent of patients who took rituximab > combinations were greatly improved. One-third of patients on rituximab alone > were greatly improved. But only 13 percent of those on the standard drug > alone improved that much. > > "One of the things that is truly unique is that a very short course ... > appears to have a very long-lasting effect," Klippel said. > > Some doctors, including the study's authors, said rituximab needs more > testing before any widespread use. They said other B-cell-killing drugs are > under development and could eventually outperform rituximab. > > Researchers are also testing similar targeted approaches against lupus, > multiple sclerosis and other autoimmune diseases. > > Both methotrexate and cyclophosphamide are sometimes employed as > chemotherapy drugs and attack a broader range of tissue than rituximab. The > newer drug kills close to 90 percent of B cells, which the body then > replenishes with healthy new ones. > > Rituximab is one of the most narrowly aimed and efficient members in the > modern family of targeted drugs that include the breast cancer treatment > Herceptin. > > Of all the tested treatments for rheumatoid arthritis, "it goes closest to > the root of the disease," said the study's lead author, Dr. Jonathan Edwards > of University College London. > > However, the drug could pose a danger of chest infection, especially if > given repeatedly, Edwards said. One rituximab patient in the study died of > pneumonia, though it was not clear if the drug was responsible. > >
"Michael Balutescu" news:40d680be$0$16106$afc38c87@news.optusnet.com.au... > Guys, when chemistry is involved is not good. Arthritis is generated by an > over-active immune system, this means that the body attacks itself. > > I suffered terrible pain as well. My left hip and ankle were very stiff and > when it was to step upstairs always I was bending only the right leg and the > exercise was still very painful. > > I've tried many medicines and nutritional supplements including the ones I > consider the best in the world (Reliv) but the enhancements were always > minor and not lasting. > > But my research paid off: I discovered the best for my condition, namely the > best immune system moderator in the world: this is called Transfer Factor in > combination with a strong anti-oxidant (Choice 50). Well, in only 2 weeks my > pain disappeared and in one month my joints were as in my youth (I am 60 > now). > > Due to the spectacular results I joined the distribution network for such > miracle products. I am really sorry to tell you about the business when you > suffer atrocious pain, but this is only my excuse coming from the bottom of > my heart for being obliged to send you to the sites where you could find > best information. These are: > Reported for advertising. This man has no shame. Harv
"Michael Balutescu" news:40d680be$0$16106$afc38c87@news.optusnet.com.au... > Guys, when chemistry is involved is not good. Ah, then you're giving up driving your car, or drinking purified water, or using a computer? After all, the demon chemistry is involved in all those things, and that's not good, is it? But, of course, the whole object of this vaguely ominous handwaving is to steer unsuspecting sufferers to your untested and unproven brand of supplements. The fact that the study the article I posted references shows real, long-lasting relief doesn't matter at all. Nope, can't have those suckers, er, I mean customers, er, I mean fellow sufferers, that's right, fellow sufferers, using something that might work, can we? That might mean you'd make less money! You'd think that every human being has a conscience, that would keep them from this kind of blatant exploitation of people in pain. You'd think, if nothing else, that we'd all have some degree of shame that would keep us from so plainly demonstrating our lack of concern for anything other than lining our own pockets at the expense of the sick and infirm. But you'd be wrong. Katherine
Don't you feel a bit guilty preying on those who have a real disease and promoting quack products? Michael Balutescu wrote: > Guys, when chemistry is involved is not good. Arthritis is generated by an > over-active immune system, this means that the body attacks itself. > > I suffered terrible pain as well. My left hip and ankle were very stiff and > when it was to step upstairs always I was bending only the right leg and the > exercise was still very painful. > > I've tried many medicines and nutritional supplements including the ones I > consider the best in the world (Reliv) but the enhancements were always > minor and not lasting. > > But my research paid off: I discovered the best for my condition, namely the > best immune system moderator in the world: this is called Transfer Factor in > combination with a strong anti-oxidant (Choice 50). Well, in only 2 weeks my > pain disappeared and in one month my joints were as in my youth (I am 60 > now). > > Due to the spectacular results I joined the distribution network for such > miracle products. I am really sorry to tell you about the business when you > suffer atrocious pain, but this is only my excuse coming from the bottom of > my heart for being obliged to send you to the sites where you could find > best information. These are: > > http://www.4-life.com > > http://www.wellnesswatch.net > > and the last one from where you could buy these products (please consider > the above excuses) is: > > http://www.my4life.com/choice > > I hope you'll find this piece of info useful. > > Regards, > > Michael Balutescu > > "Katherine Wolfe" > news:cb349j02rk1@enews1.newsguy.com... > >>I read this article on cnn.com, and thought of you guys. Looks like there >>will be a new class of rheumatoid arthritis drugs coming along..... >> >>Katherine >> >>==================================== >> >> > > http://www.cnn.com/2004/HEALTH/conditions/06/18/arthritis.drug.ap/index.html > >>Drug makes 'smart' assault on arthritis >> >>BOSTON, Massachusetts (AP) -- For the first time, a drug has relieved >>rheumatoid arthritis by knocking out a certain type of immune cell -- an >>approach that could open the way for precisely targeted, "smart" > > treatments > >>for the joint disease and other illnesses, too. >> >>Other arthritis drugs on the market either treat just the symptoms, or >>employ a broader, more scattershot effect against the underlying process. >>Such drugs can have toxic side effects because they kill healthy cells > > along > >>with the diseased ones. >> >>The latest research, an international study led at University College > > London > >>and published in Thursday's New England Journal of Medicine, looked at a >>drug called rituximab, and the results were promising. >> >>"I think this is a pivotal study," said Dr. John Klippel, president of the >>Arthritis Foundation. "This is opening up a new era of targeted biologic >>therapies for rheumatoid arthritis." >> >>In rheumatoid arthritis, antibodies misdirect friendly fire against the >>body's own joint linings. Joints become inflamed, swollen and painful. > > More > >>than 2 million Americans, mostly women, have the disease. >> >>Rituximab, which is sold under the brand name Rituxan and is already >>approved for non-Hodgkin's lymphoma, targets B cells, which manufacture >>these antibodies. >> >>The researchers compared rituximab to other drugs in 161 patients with >>arthritis. >> >>For two weeks, patients took rituximab alone or in combination with two >>other drugs: the standard drug, methotrexate, and the less widely used >>cyclophosphamide. Another group took methotrexate alone. Roche, a >>distributor of rituximab, funded and participated in the study. >> >>After six months, more than 40 percent of patients who took rituximab >>combinations were greatly improved. One-third of patients on rituximab > > alone > >>were greatly improved. But only 13 percent of those on the standard drug >>alone improved that much. >> >>"One of the things that is truly unique is that a very short course ... >>appears to have a very long-lasting effect," Klippel said. >> >>Some doctors, including the study's authors, said rituximab needs more >>testing before any widespread use. They said other B-cell-killing drugs > > are > >>under development and could eventually outperform rituximab. >> >>Researchers are also testing similar targeted approaches against lupus, >>multiple sclerosis and other autoimmune diseases. >> >>Both methotrexate and cyclophosphamide are sometimes employed as >>chemotherapy drugs and attack a broader range of tissue than rituximab. > > The > >>newer drug kills close to 90 percent of B cells, which the body then >>replenishes with healthy new ones. >> >>Rituximab is one of the most narrowly aimed and efficient members in the >>modern family of targeted drugs that include the breast cancer treatment >>Herceptin. >> >>Of all the tested treatments for rheumatoid arthritis, "it goes closest to >>the root of the disease," said the study's lead author, Dr. Jonathan > > Edwards > >>of University College London. >> >>However, the drug could pose a danger of chest infection, especially if >>given repeatedly, Edwards said. One rituximab patient in the study died of >>pneumonia, though it was not clear if the drug was responsible. >> >> > > > 1 2 Next » Related Discussion: Live a better and sefer life!! (1 posts) I FOUND THE BEST CANADIAN ONLINE PHARMACY! (1 posts) Heart Attacks More Likely For People With High Blood Pressure In Cold Weather (1 posts) Rheumatoid arthritis and systemic Lupus Erythematosus. (1 posts) Top Discussions From Our Archives FREE MAGNETIC HEALING RINGS FREE Other Discussion Categories Diabetes Symptoms Health Care Policy Oops!!! Unexpected Error While Reading the Feed
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