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possible rationale for bloodletting / inflammation
possible rationale for bloodletting / inflammation -- Posted by doe on 07-02-04 13:02
Scand J Gastroenterol. 2004 May;39(5):416-7. Related Articles, Links
Selective bloodletting for severe ulcerative colitis.
Premehand P, Takeuchi K, Bjarnason I.
Dept. of Gastroenterology, King's College Hospital, London, UK.
ppremchand100@yahoo.com
PMID: 15180176 [PubMed - in process]
Seems to compare .. apheresis TO .. bloodletting ..
Same result .. different methods and expense ..
<>
With current insight into the pathogenesis of various 'inflammatory' diseases ,
and the involvement of circulating cells, cytokines and other cell-cell
signalling molecules, a possible rationale for bloodletting emerges, i.e.
removal of pro-inflammatory cells or substances thereby interrupting a viscous
cycle whereby effector molecules perpetuate inflammation.
The Japanese experience in ulcerative colitiis , if confirmed in controlled
trials , has the potential to alter our approach to the treatment of severe
exacerbation of ulcerative colitis, thus obviating the need for surgery, which
is associated with significant morbidity.
While the precise mechansim of benefit of this treatmemt is not fully
understood , the apheresis systems are also showing promise in Crohn disease .
We suggest that this may herald a new therapeutic approach whereby speciific
constituents of blood are removed rather than neurtralized with antibodies ,
which are unavoidably associated with tolerance and side effects.
<>
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