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Flavanol-rich cocoa drink / oxidative stress
Flavanol-rich cocoa drink / oxidative stress -- Posted by doe on 07-04-04 13:24
Free Radic Biol Med. 2004 Aug 1;37(3):411-21. Related Articles, Links
Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in
humans.
Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe T, Sies H.
Institut fur Klinische Chemie und Pathobiochemie, Otto-von-Guericke-Universitat
Magdeburg, Germany.
Flavan-3-ols are potent antioxidants in vitro, but convincing evidence for
antioxidant action in vivo is lacking. We examined whether an oxidative
stress-mediated increase in plasma F(2)-isoprostanes is counteracted by a
flavanol-rich cocoa beverage. Twenty volunteers were examined in a comparative
randomized double-blind crossover design with respect to ingestion of
high-flavanol cocoa drink (HFCD; 187 mg flavan-3-ols/100 ml) vs. low-flavanol
cocoa drink (LFCD; 14 mg/100 ml). With 10 individuals, the treatment was
combined with strenuous physical exercise. Total (esterified plus
nonesterified) F(2)-isoprostanes were analyzed by GC/MS. LFCD caused a slight
increase in the mean (+/- SEM) plasma concentrations of F(2)-isoprostanes 2 and
4 h after intake (2.16 +/- 0.19 nM at 4 h vs. 1.76 +/- 0.11 nM at 0 h, n = 10),
which may be attributable to postprandial oxidative stress. This increase did
not occur with HFCD (1.57 +/- 0.06 nM at 4 h vs. 1.65 +/- 0.10 nM at 0 h, n =
10). The difference in F(2)-isoprostanes 2 and 4 h after intake of HFCD vs.
LFCD became statistically significant when the intake was combined with
physical exercise (P < 0.01, ANOVA). We conclude that dietary flavanols, using
cocoa drink as example, can lower the plasma level of F(2)-isoprostanes,
indicators of in vivo lipid peroxidation.
PMID: 15223075 [PubMed - in process]
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