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leukocytapheresis therapy in rheumatoid arthritis
leukocytapheresis therapy in rheumatoid arthritis -- Posted by doe on 07-12-04 12:49
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The results indicate that filtration LCP is an effective and well-tolerated
treatment for patients with drug-resistant RA.
<>
Clinical Science
Filtration leukocytapheresis therapy in rheumatoid arthritis: A randomized,
double-blind, placebo-controlled trial
Toshihiko Hidaka *, Kimihiro Suzuki, Yasunori Matsuki, Mitsuyo
Takamizawa-Matsumoto, Kouji Kataharada, Toshiaki Ishizuka, Makoto Kawakami,
Haruo Nakamura
National Defense Medical College, Saitama, Japan
*Correspondence to Toshihiko Hidaka, Internal Medicine I, National Defense
Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
Abstract
Objective
To determine the efficacy and safety of filtration leukocytapheresis (LCP) for
the treatment of rheumatoid arthritis (RA).
Methods
Twenty-five patients with drug-resistant RA were randomly assigned to undergo
filtration LCP and 7 to undergo sham apheresis (control group) in a randomized,
double-blind, placebo-controlled study. Three apheresis procedures were
performed, with 1-week intervals between procedures. The efficacy of filtration
LCP was evaluated according to the American College of Rheumatology definition
of improvement in RA. Medications for each patient were unchanged for at least
6 months prior to enrollment and throughout the study.
Results
Tender joint counts, swollen joint counts, patient assessment of pain and
global severity, physician assessment of global severity, and Health Assessment
Questionnaire Disability Index were significantly improved in the LCP group
compared with the control group (P < 0.05 for patient assessment of pain; P <
0.01 for all others). Seventy-nine percent of the patients in the LCP group
exhibited significant overall improvement, while none of the patients in the
control group were improved (P < 0.001).
Conclusion
The results indicate that filtration LCP is an effective and well-tolerated
treatment for patients with drug-resistant RA.
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Received: 24 April 1998; Accepted: 22 September 1998
Digital Object Identifier (DOI)
10.1002/1529-0131(199904)42:3<431::AID-ANR6>3.0.CO;2-2 About DOI
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