---
Phytic acid / anti-inflammatory / anti-ulcer / iron binder
Phytic acid / anti-inflammatory / anti-ulcer / iron binder -- Posted by doe on 08-01-04 11:17
Indian J Exp Biol. 2004 Feb;42(2):179-85. Related Articles, Links
Antiinflammatory and antiulcer activities of phytic acid in rats.
Sudheer Kumar M, Sridhar Reddy B, Kiran Babu S, Bhilegaonkar PM, Shirwaikar A,
Unnikrishnan MK.
Department of Pharmacology, College of Pharmaceutical Sciences, Manipal 576
119, India.
Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose
of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed
ability to prevent denaturation of proteins, it showed less antiinflammatory
activity than ibuprofen. Ability of PA to bring down thermal denaturation of
proteins might be a contributing factor in the mechanism of action against
inflammation. PA, at all the doses tested, showed significant protection from
ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity
at 150 mg/kg. There was a significant increase in gastric tissue
malondialdehyde levels in ethanol treated rats but these levels decreased
following PA pretreatment. Moreover, pretreatment with PA significantly
inhibited various effects of ethanol on gastric mucosa, such as, reduction in
the concentration of nonprotein sulfhydryl groups, necrosis, erosions,
congestion and hemorrhage. These results suggested that gastro-protective
effect of PA could be mediated by its antioxidant activity and cytoprotection
of gastric mucosa.
PMID: 15282951 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Related
Discussion:
Longevity and Health (1 posts)
by Dr. Anthony Taylor - Last post on: 11-08-04 00:25
hi everybody, I found a very interesting book on longevity and health! You must check it out:
http://templeofnature.org/book
I hope it can save your health. I love it! This info is so true!
Dr. Anthony Taylor
---
MAF Anti-Spam ID: 20041107170658Q9m1KyA3
... (Read More)
Heat versus cold? (3 posts)
by Nzuri - Last post on: 03-13-05 06:53
Greetings from southern England,
Have just found your excellent newsgroup! I'm posting on behalf of my
mum who is - according to her doctor - suffering from a severe
flare-up of arthritis in her back. Like most 78 year olds, it seems,
she has suffered from attacks of arthritis from time to t... (Read More)
(1 posts)
by @ - Last post on: 09-29-05 00:00
... (Read More)
Specialist? (3 posts)
by Confused Man - Last post on: 09-13-05 20:22
Hello all,
this may seem a stupid question, and if so I sincerly apologize... but if
I'm looking for a doctor who specializes in Diabetes.... what would be the
official term for that specialty? I'm looking through my health insurances
"Doc Find" and searching by specialty but honestly have ... (Read More)
Top
Discussions From Our Archives
Symptoms
Free samples for pain management
Other
Discussion Categories
Diabetes Symptoms
Health Care Policy
| 
