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OOPS / rheumatoid arthritis / iron
OOPS / rheumatoid arthritis / iron -- Posted by doe on 08-04-04 20:46
The snip tells the tale .. the USUAL method failed to assess iron parameters
correctly allowing for the doctors to give her iron until it .. seems to ..
almost .. kill .. her ..
<>
The
routine method for determining serum Fe concentration in our hospital is direct
photoscopic assay. When we assayed serum Fe concentration by a deproteinization
method, it showed a higher value
<>
Rinsho Byori. 2000 Aug;48(8):730-3. Related Articles, Links
[A case of hemophagocytosis syndrome with excessive Fe and ferritin
concentration in serum and with a good prognosis]
[Article in Japanese]
Maekawa M, Hara K.
Clinical Laboratory, National Cancer Center Hospital, Tokyo.
Investigation in the present case began with a high serum Fe concentration. The
routine method for determining serum Fe concentration in our hospital is direct
photoscopic assay. When we assayed serum Fe concentration by a deproteinization
method, it showed a higher value. We also measured serum ferritin
concentration, and suspected that high ferritin interfered with serum Fe
concentration. We checked the dose-dependent effect of ferritin on serum Fe
determination. The present case, a 64-year-old female, showed a reduction of
Plt count, and an elevation of LDH, CRP and so on, meeting most of the criteria
for hemophagocytosis syndrome. Bone marrow smears revealed phagocytosis of
blood cells. The present case had been followed for rheumatoid arthritis and
medicated with oral iron pills. In her liver and spleen, high amounts of Fe had
accumulated, and excessive Fe was being released into the blood by any trigger,
such as infection, stress, cytokine activation, and/or HPS.
Publication Types:
Case Reports
PMID: 11064596 [PubMed - indexed for MEDLINE]
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