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Immune system / antioxidants
Immune system / antioxidants -- Posted by doe on 04-25-04 17:37
<>
it was established that the activity of the oxidant-antioxidant system (OAS)
correlates not only with a severity of the inflammatory reaction but also with
a degree of immune disorders
<>
Which means .. low antioxidants = low immune system / increased immune system
disturbance ..
Vestn Ross Akad Med Nauk. 2004;(2):34-40. Related Articles, Links
[In Process Citation]
[Article in Russian]
[No authors listed]
On the basis of the understanding that there are common development mechanisms
for the inflammatory and immune reactions it was established that the activity
of the oxidant-antioxidant system (OAS) correlates not only with a severity of
the inflammatory reaction but also with a degree of immune disorders. Such
disorders were studied in patients with endogenous uveitis and with cancer of
the esophagus or uterine cervix, i.e. those nosological forms, which are
normally accompanied by OAS decompensation, which comprised a lower activity of
primary antioxidants (superoxides of dismutase, catalase, lactoferrin,
ceruloplasmin etc.) in patients with pronounced immune disorders. Moreover, a
lower content of secondary antioxidants, like vitamin A, ascorbic acid and
tocopherol, was registered in the blood of patients with immune disorders. The
suppression of the antioxidant system was concomitant with an essentially
increased level of lipid peroxidation in all patients. Besides, it was noted
that there were intensifying signs of immune disorders primarily observed
during irradiation chemotherapy. In this context, a clear-cut correlation was
established, in monitoring the body immune status, between degrees of
free-radical formation and lipid peroxidation, on the one hand, and an activity
of detoxication-system antioxidants, on the other hand,. The OAS correction by
direct or indirect-action antioxidants normally improves the clinical course of
immune impairments. The indirect-action antioxidants, e.g. synthetic regulatory
peptide "Imunofan", induce the increasing activity of primary endogenous
antioxidants. An activation of the detoxication antioxidant system, brings
about, in such cases, a lower content of inflammation mediators, a recovery of
cell-immunity indices and lower parameters of body auto-sensitization. Finally,
the antioxidant system in patients with chronic inflammatory or oncological
disorders, when recovered, ensures the correction of cell immunity and cuts the
number of auto-immune reactions and of other immune disturbances.
PMID: 15101207 [PubMed - in process]
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