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Persistant Chronic fatigue / iron
Persistant Chronic fatigue / iron -- Posted by doe on 09-18-04 16:13
Almost fifty percent have HIGH .. ferritin / iron
<>
high prevalence (38%) of serum ferritin >/= 300 microg/l must be EMPHASIZED
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Rev Med Interne. 2004 Sep;25(9):623-628. Related Articles, Links
[Haemochromatosis screening in 120 patients complaining with persistant
fatigue]
[Article in French]
Durand DV, Francois S, Nove-Josserand R, Durupt S, Durieu I, Morel Y, Rousset
H.
Service de medecine interne, universite Lyon-I, centre hospitalier Lyon Sud,
69495 Pierre-Benite cedex, France.
Aim. - Chronic fatigue is the more frequent symptom identified in the course of
hereditary haemochromatosis. A screening for this disorder was carried out in
120 primary care patients consulting for unexplained chronic fatigue. Subjects
and methods. - Transferrin saturation and serum ferritin were determined in all
patients. If transferrin saturation was >/= 45% and serum ferritin >/= 300
microg/l, HFE1 genotyping for mutations C282Y and H63D was completed. Results.
- One hundred and twenty patients were recruited, 19-86 years old, including 62
males and 58 females. 45 patients (38%) presented with serum ferritin >/= 300
microg/l. Thirty two patients (27%) presented with transferrin saturation >/=
45%. Twenty two patients (18%) presented with these two pathological values.
Four C282Y/H63D compound heterozygous, one H63D/H63D homozygous, and eight
simplex heterozygous (6 H63D and 2 C282Y) genotypes were found. Patients with
serum ferritin >/= 300 microg/l were predominantly male (89%), older (57 year)
and plethoric (BMI: 26.4) corresponding mainly to dysmetabolic
hyperferritinemia. Conclusion. - None of these 120 patients consulting for
unexplained chronic fatigue was found with hereditary haemochromatosis.
Therefore observed prevalence is 0, with upper limit of 95% confidence interval
at 2.5%. But the high prevalence (38%) of serum ferritin >/= 300 microg/l must
be emphasized, corresponding usually to dysmetabolic hyperferritinemia.
PMID: 15363617 [PubMed - as supplied by publisher]
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