---
Iron / infection
Iron / infection -- Posted by doe on 11-09-04 03:51
Nature. 2004 Nov 7 [Epub ahead of print] Links
Lipocalin 2 mediates an innate immune response to bacterial infection by
sequestrating iron.
Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem
A.
[1] Institute for Systems Biology, Seattle, Washington 98103, USA [2] Institute
for Cancer Research and Molecular Medicine, Norwegian University of Science and
Technology, 7489 Trondheim, Norway [3] These authors contributed equally to
this work.
Although iron is required to sustain life, its free concentration and
metabolism have to be tightly regulated. This is achieved through a variety of
iron-binding proteins including transferrin and ferritin. During infection,
bacteria acquire much of their iron from the host by synthesizing siderophores
that scavenge iron and transport it into the pathogen. We recently demonstrated
that enterochelin, a bacterial catecholate siderophore, binds to the host
protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the
innate immune response to bacterial infection. Upon encountering invading
bacteria the Toll-like receptors on immune cells stimulate the transcription,
translation and secretion of lipocalin 2; secreted lipocalin 2 then limits
bacterial growth by sequestrating the iron-laden siderophore. Our finding
represents a new component of the innate immune system and the acute phase
response to infection.
PMID: 15531878 [PubMed - as supplied by publisher]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Related
Discussion:
Re: Take advantage of the Health Care Crisis! (1 posts)
by Karaokecd - Last post on: 09-21-03 13:41
In article
"Spaz" wrote:
>
> AllaboardUSA.com is an online marketing powerhouse. It works 24 hours a
> day, 7 days a week, 365 days a year.
Flush.
... (Read More)
Underarm/side pain and breast soreness (2 posts)
by Melanie via MedKB.com - Last post on: 03-26-05 22:38
I have been experiencing underarm pain that runs all the way to my
shoulderblades.... especially on the left side. This usually worsens when
I have my monthly period.
Picking up my child also worsens the pain. The pain was so bad at one
point, I had to put a heating pad on my side just so I co... (Read More)
Prevention of type 2 diabetes mellitus through inhibition of the Renin-Angiotensin system. (1 posts)
by Gumbo - Last post on: 12-12-04 06:32
Prevention of type 2 diabetes mellitus through inhibition of the
Renin-Angiotensin system.
Scheen AJ.
Division of Diabetes, Department of Medicine, Nutrition and Metabolic
Disorders, CHU Sart Tilman, Liege, Belgium.
Type 2 diabetes mellitus is becoming a major health problem associated ... (Read More)
Iron induced osteopenia (10 posts)
by ironjustice@aol.com - Last post on: 08-05-05 10:56
Toxicol Pathol. 2005;33(5):533-9. Related Articles, Links
Ultrastructural and morphometrical evaluation of the parathyroid gland
in iron-lactate-overloaded rats.
Matsushima S, Tsuchiya N, Fujisawa-Imura K, Fujisawa-Imura K, Hoshimoto
M, Takasu N, Torii M, Ozaki K, Narana I, Kotani T.
Pa... (Read More)
Top
Discussions From Our Archives
Freeloading illegal aliens accuse US nurses of spreading lice
www.mywinwebpage.com/almere
Two-In-One Diabetes Medications
Tantric Gems back issues ===== uE0
Other
Discussion Categories
Diabetes Symptoms
Health Care Policy
Health Care Providers HMO
Arthritis Symptoms
| 
