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Celebrex affects process that regulates pH in cells, impact unknown: study
Celebrex affects process that regulates pH in cells, impact unknown: study -- Posted by Roman Bystrianyk on 11-11-04 17:32
http://www.healthsentinel.com/news.php?event=news_print_list_item&id=388
"Celebrex affects process that regulates pH in cells, impact unknown:
study", Canada.com, November 11, 2004,
Link: http://www.canada.com/health/story.html?id=84e15537-7b21-48cc-ae07-b81e521eb283
Researchers at the University of Alberta have found that the
anti-inflammatory drug Celebrex affects a basic biological process
that regulates pH in cells.
But what effect this has on the whole body is not known. And other
scientists say it's intriguing but insignificant in the debate on the
link between heart attacks and strokes and arthritis drugs such as
Celebrex and Vioxx.
Joseph Casey, a physiology professor at the university, said his study
found celecoxib, the scientific name for the drug Celebrex, reduces
the process that transports bicarbonate into and out of cells.
Bicarbonate lowers or raises the pH level - the level of acidity - in
cells.
"It is known that bicarbonate does play a role in normal heart
function and is important during the time surrounding a heart attack,
so any inference between our data and cardiovascular risk is
indirect."
Scientists are questioning the safety of drugs known as Cox-2
inhibitors since Vioxx was pulled from the market at the end of
September after a study showed it doubled the risk of heart attack and
stroke.
Casey said he cannot say whether the inhibition of bicarbonate into
cells increases the risk of cardiovascular problems because his study
did not look at that.
"We can't say that it increases risk. All we can say is that there is
another pathway being affected by this drug and there is a theoretical
link between effects on bicarbonate transport and effects on the
heart.
"In theory it could explain adverse cardiovascular events."
Casey's study will be published in the Nov. 23 issue of Molecular
Membrane Biology, a British scientific journal.
Dr. Muhammad Mamdani, senior scientist with the Institute for Clinical
Evaluative Sciences at Toronto's Sunnybrook Hospital, said Casey's
findings are "intriguing and worth exploring."
"This is one mechanism out of millions of mechanisms in the body, it's
a complex system. So what does this mean in terms of actual
implications for heart attacks, for cardiovascular outcomes, this is
not conclusive. It doesn't tell us much of anything."
Mamdani said he wouldn't advise patients to stop taking Celebrex due
to Casey's findings.
Dr. Mark Fendrick, an internal medicine specialist at the University
of Michigan Health System in Ann Arbour, Mich., agreed.
"I don't think anyone would make high-level clinical or regulatory
decisions based on a surrogate marker such as bicarbonate transport .
. . it's certainly not going to be enough to tip the scales."
Fendrick said patients who have an increased risk of coronary heart
disease should not be taking Cox-2 drugs because of the possibility
that they may increase the risk of heart attack and stroke.
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