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Scientist raises estimate of Vioxx ill-effects
Scientist raises estimate of Vioxx ill-effects -- Posted by Roman Bystrianyk on 01-02-05 16:26
http://www.healthsentinel.com/news.php?event=news_print_list_item&id=510
Andrew Jack, "Scientist raises estimate of Vioxx ill-effects",
Financial Times, January 2, 2005,
Link:
http://news.ft.com/cms/s/b9967e4a-5cf0-11d9-bb9c-00000e2511c8.html
The scientist at the centre of a dispute over the safety of the
anti-inflammatory Vioxx has vowed to publish research that suggests up
to 139,000 Americans have died or have been seriously injured as a
result of taking the drug.
The likely appearance in the Lancet of a revised version of a paper by
Dr David Graham, an employee of the Food and Drugs Administration, will
fuel debate over the effectiveness of the US drug regulatory system and
may spur additional litigation against Merck, the manufacturer of
Vioxx.
Dr Graham originally estimated in August that 28,000 Americans had died
or suffered debilitating heart attacks as a result of taking Vioxx
since it was first approved in 1999. His research sparked a debate that
has since forced regulators to call into doubt the safety of the entire
cox-2 inhibitor class of drugs to which Vioxx belongs.
In an interview with the FT, Dr Graham said he was determined to go
ahead with publication of his updated analysis, even though he had been
threatened with dismissal by the FDA if he wrote and published the
paper.
"The FDA has suppressed the paper and maligned me in the media but
never responded. The proper place for scientific information is in a
peer-reviewed scientific journal," he said.
The FDA only allowed him to present the data in his personal capacity
and banned him from publishing it in the Lancet. A few weeks later,
Merck withdrew Vioxx, claiming it had done so voluntarily and
identified health risks in its own study.
Re-analysing the data, including recent information from Merck's study,
Dr Graham said that between 89,000 and 139,000 people had been
seriously affected by the drug. He originally provided those estimates
to a congressional hearing in November.
Re: Scientist raises estimate of Vioxx ill-effects -- Posted by Williams on 01-03-05 08:20
Roman Bystrianyk wrote:
>
http://www.healthsentinel.com/news.php?event=news_print_list_item&id=510
>
> Andrew Jack, "Scientist raises estimate of Vioxx ill-effects",
> Financial Times, January 2, 2005,
> Link:
> http://news.ft.com/cms/s/b9967e4a-5cf0-11d9-bb9c-00000e2511c8.html
>
> The scientist at the centre of a dispute over the safety of the
> anti-inflammatory Vioxx has vowed to publish research that suggests
up
> to 139,000 Americans have died or have been seriously injured as a
> result of taking the drug.
>
> The likely appearance in the Lancet of a revised version of a paper
by
> Dr David Graham, an employee of the Food and Drugs Administration,
will
> fuel debate over the effectiveness of the US drug regulatory system
and
> may spur additional litigation against Merck, the manufacturer of
> Vioxx.
>
> Dr Graham originally estimated in August that 28,000 Americans had
died
> or suffered debilitating heart attacks as a result of taking Vioxx
> since it was first approved in 1999. His research sparked a debate
that
> has since forced regulators to call into doubt the safety of the
entire
> cox-2 inhibitor class of drugs to which Vioxx belongs.
>
> In an interview with the FT, Dr Graham said he was determined to go
> ahead with publication of his updated analysis, even though he had
been
> threatened with dismissal by the FDA if he wrote and published the
> paper.
>
> "The FDA has suppressed the paper and maligned me in the media but
> never responded. The proper place for scientific information is in a
> peer-reviewed scientific journal," he said.
>
> The FDA only allowed him to present the data in his personal capacity
> and banned him from publishing it in the Lancet. A few weeks later,
> Merck withdrew Vioxx, claiming it had done so voluntarily and
> identified health risks in its own study.
>
> Re-analysing the data, including recent information from Merck's
study,
> Dr Graham said that between 89,000 and 139,000 people had been
> seriously affected by the drug. He originally provided those
estimates
> to a congressional hearing in November.
Many people don't realize it, but being DEAD, BLIND, PARALYZED, or
BRAIN DAMAGED is not worth the risk of taking something that is NO
better than an ibuprofen.
Countless other incidents may have occurred in the form of transient
ischemic attacks - which leave no footprint.
Re: Scientist raises estimate of Vioxx ill-effects -- Posted by David Wright on 01-03-05 21:10
In article <1104769210.637301.219230@f14g2000cwb.googlegroups.com>,
Williams wrote:
>Roman Bystrianyk wrote:
>Many people don't realize it, but being DEAD, BLIND, PARALYZED, or
>BRAIN DAMAGED is not worth the risk of taking something that is NO
>better than an ibuprofen.
That's true -- but when I took Vioxx, it was *way* better than
ibuprofen. I was astounded.
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"If I have not seen as far as others, it is because giants
were standing on my shoulders." (Hal Abelson, MIT)
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