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--- Aspirin Risks In Healthy Individuals
"Roman Bystrianyk" news:1105902870.848363.318300@z14g2000cwz.googlegroups.com... > http://www.healthsentinel.com/org_news.php?event=org_news_print_list_item&id=16 > > Roman Bystrianyk, "Aspirin Risks In Healthy Individuals", Health > Sentinel, January 16, 2005, > > Felix Hoffman at Bayer Industries synthesized aspirin over 100 years > ago. Today there have been many ads promoting aspirin's potential to > reduce the risk of heart attack and stroke in certain people. However, > the decision to use aspirin as a preventative is not as simple as it > looks. What generally has not been analyzed are the risks and costs > associated with aspirin therapy. > > In the January issue of The Annals of Pharmacotherapy the authors > analyze the lifetime cumulative risk, the potential negative effects on > quality-adjusted-life-years (QALYs), life expectancy, and cost of > aspirin therapy. The authors construct a model of healthy individuals > starting at age 50 taking a 325 mg enteric-coated daily aspirin. Based > on numerous references the authors take into account adverse effects > such as upper gastrointestinal bleeding, quality of life factor, and > aspirin cost. > > Based on their analysis, aspirin therapy only had a modest negative > effect on both QALYs and life expectancy. The average lifetime cost was > determined to be $460 per person. > > However, the authors found that, "for every 15 healthy 50-year-old > men started on aspirin therapy, one will have a complication in his > lifetime; for every 556 individuals started on aspirin therapy, one > will die from complications." Comparison of death risk of lifetime > aspirin therapy (1 in 556) versus other mortality risks were listed as > follows: hip surgery (1 in 345), cardiac catheterization (1 in 500), > general anesthesia (1 in 3,685), annual accidents (1 in 3,014), food > poisoning (1 in 56,424), sky diving (1 in 70,130 per dive), and yearly > driving with a cell phone (1 in 76,900). > > The authors also note that, "starting aspirin at an earlier age > resulted in a larger absolute reduction in both QALYs and life > expectancy, increased cost, and not surprisingly, a greater number of > complications." > > The authors also analyzed the use of proton pump inhibitors (PPIs) to > reduce the aspirin risk. They determined a modest increase in quality > of life and life expectancy, but at a substantial increase in cost. The > addition of PPIs resulted in an increase from an average lifetime cost > of $460 per person to $18,400. > > The authors do not attempt to incorporate all the potential benefits of > aspirin, as the aim of the study was to determine the risk. The authors > also note that, "although good published data exist to accurately > model the drawbacks of aspirin therapy, the benefits of aspirin in > cancer chemoprevention are preliminary at best and will likely not be > apparent for at least 10 years of aspirin therapy. Short-term data for > the efficacy of aspirin for the prevention of primary coronary events > exist, but long-term data are currently unavailable." > SOURCE: The Annals of Pharmacotherapy, January 2005 I wonder why they studied "full strength" aspirin (325 mg). Most recommendations I've seen are for "baby" aspirin (81 mg). GG
"GaryG" news:1wzGd.15327$IF3.3665@fe05.lga... > > I wonder why they studied "full strength" aspirin (325 mg). Most > recommendations I've seen are for "baby" aspirin (81 mg). > Perhaps they were looking for adverse results (i.e. they knew the conclusion they *wanted* to reach), so did what they could to stack the deck. bj
bj > "GaryG" > news:1wzGd.15327$IF3.3665@fe05.lga... > > > > I wonder why they studied "full strength" aspirin (325 mg). Most > > recommendations I've seen are for "baby" aspirin (81 mg). > > > > Perhaps they were looking for adverse results (i.e. they knew the conclusion > they *wanted* to reach), so did what they could to stack the deck. > bj No, for keeping stents, PTAs and arteries in general 'clean' the 81mg is theoretically sufficient (every second day in fact) assuming you are the standard 70kg male. For the supposed cancer prophylaxis higher doses (100-400mg/day) are recommended by various authors. madiba
"madiba" > bj > > > "GaryG" > > news:1wzGd.15327$IF3.3665@fe05.lga... > > > > > > I wonder why they studied "full strength" aspirin (325 mg). Most > > > recommendations I've seen are for "baby" aspirin (81 mg). > > > > > > > Perhaps they were looking for adverse results (i.e. they knew the conclusion > > they *wanted* to reach), so did what they could to stack the deck. > > bj > > No, for keeping stents, PTAs and arteries in general 'clean' the 81mg is > theoretically sufficient (every second day in fact) assuming you are the > standard 70kg male. For the supposed cancer prophylaxis higher doses > (100-400mg/day) are recommended by various authors. > > madiba Source?
menu boy > "madiba" > > bj > > > > > "GaryG" > > > news:1wzGd.15327$IF3.3665@fe05.lga... > > > > > > > > I wonder why they studied "full strength" aspirin (325 mg). Most > > > > recommendations I've seen are for "baby" aspirin (81 mg). > > > > > > > > > > Perhaps they were looking for adverse results (i.e. they knew the > > > conclusion they *wanted* to reach), so did what they could to stack > > > the deck. bj > > > > No, for keeping stents, PTAs and arteries in general 'clean' the 81mg is > > theoretically sufficient (every second day in fact) assuming you are the > > standard 70kg male. For the supposed cancer prophylaxis higher doses > > (100-400mg/day) are recommended by various authors. > > > > madiba > > Source? Me. Any questions? :-/ Unless youre google-impaired or lived in a cave the last 10 years you must have heard of the 'wonder' drug aspirin®.. Hardly a year went by without some new benefit being attributed to long-term aspirin medication. 40mg is enough to impair platelet activity for 48hrs (this I have from way back, intern time), chronic aspirin consumption apparently helps prevent colorectal cancer, lung cancer, etc. More recent work has associated it with an increased frequency of pancreatic cancer.. So its not all positive, apart from its well-known gastric side-effects. -- madiba 1 2 3 4 5 Next » Related Discussion: Music and Chronic Pain (1 posts) bone growth / lactoferrin / iron (1 posts) Low Adherence to Guidelines for Nephropathy and Hypertension in Diabetics (1 posts) Are you a STAY-AT-HOME MOM? (1 posts) Top Discussions From Our Archives Rheumatoid Arthritis Attacks the Heart I can teach anyone how to get what they want out of life (OT) Are we a nation at risk from the flu? Alternative to Vioxx and Other Medications Hearing loss / iron / superficial siderosis Other Discussion Categories Diabetes Symptoms Health Care Policy Health Care Providers HMO Arthritis Symptoms
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