---
Re: Pseudogout
Re: Pseudogout -- Posted by camcneice@msn.com on 01-24-05 19:39
drdoc wrote:
> Susan Hoch MD wrote:
> >> Treatment is limited to steroid injections, analgiesics,
> > nonsteroidal antiinflammatory drugs, physical therapy and surgery
> > where indicated.
> >
> > Regards,
> >
> > Susan Hoch, M.D.
> >
>
> I would also add colchicine to that possible therapy list...
> Its usually used in Gout but has some efficacy in pseudogout as well
> There are many published articles....here are 2 of them..
>
>
>
> Clin Exp Rheumatol 1988 Jul;6(3):305-317
> Colchicine in therapy. State of the art and new perspectives for an
old
> drug.
>
> Famaey JP
>
> Department of Rheumatology, Hopital Universitaire Saint-Pierre,
> University of Brussels, Belgium.
>
> Colchicine is the most specific treatment in acute gouty attacks. In
> several European countries, oral colchicine is still used for
> routine treatment of acute gout. Its selectivity is used as a
diagnostic
> tool. It is also active in the treatment of acute crises of
> chondrocalcinosis and more occasionally of other arthritic crises
(e.g.
> sarcoidosis). Colchicine appears to be the necessary
> adjuvant prophylactic drug when starting a hypouricemic treatment
with
> uricosuric or uricolytic drugs for avoiding acute gouty
> crisis due to sudden mobilisation of the uric acid pool. Besides
gout,
> colchicine is the drug of choice for treating familial
> mediterranean fever. It appears to be helpful in the treatment of
> Behcet's disease. It seems also useful for treating fibrosing
> conditions such as liver cirrhosis and scleroderma. As an adjuvant
> therapy, it helps treating dermatological disorders which are
> associated with leucocyte migration as an essential pathogenic factor
> (e.g. psoriasis, dermatitis herpetiformis, necrotising
> vasculitis ...). It has been advocated as an adjuvant therapy in
> malignant diseases as a support in radiotherapy and as an useful
> drug in various other diseases where it has been tried occasionally
> (e.g. Paget's disease of the bone, idiopathic
> thrombocytopenic purpura, disc syndrome). This very old drug remains
a
> modern therapeutic agent.
>
> ================
> J Rheumatol 1986 Aug;13(4):804-805
> Colchicine prophylaxis in pseudogout.
> Alvarellos A, Spilberg I
>
> Ten patients with recurrent attacks of pseudogout were followed for 1
> year before and 1 year after receiving oral colchicine 0.6
> mg BID. Thirty-two episodes of acute arthritis were recorded in the
year
> (3.2/patient/year) before the start of the drug and only
> 10 while taking the drug (1/patient/year) (p less than 0.001). Ninety
> percent of the patients benefitted from the drug. Our study
> supports the effectiveness of oral colchicine as a prophylactic agent
in
> recurring pseudogout.
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