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Temporomandibular disorders / iron
Temporomandibular disorders / iron -- Posted by ironjustice@aol.com on 02-22-05 02:50
<>
iron-dependent generation of HO( *) might have a crucial role in the
pathogenesis of temporomandibular disorders
<>
Redox Rep. 2004;9(6):331-6. Links
Evidence of reactive oxygen species generation in synovial fluid from
patients with temporomandibular disease by electron spin resonance
spectroscopy.
Lee MC, Kawai Y, Shoji H, Yoshino F, Miyazaki H, Kato H, Suga M, Kubota
E.
Department of Clinical Care Medicine, Division of Pharmacology and ESR
Laboratories, Yokosuka, Japan.
Reactive oxygen species (ROS) have been implicated in the pathogenesis
of temporomandibular disorders. In the present study, we provide the
first evidence of ROS generation in the synovial fluid from human
temporomandibular disorder patients, as shown by electron spin
resonance (ESR) and spin trapping. Three distinct ESR spectra of DMPO
spin adducts were observed in the synovial fluid. They corresponded to
three free radical species: hydroxyl radical (HO(*)), hydrogen radical
(H(*)), and carbon-center radical (R(*)). Among them, the
5,5-dimethyl-1-pyrroline-N-oxide (DMPO)-OH spectrum was the most
prominent, suggesting that HO(*) was dominantly generated in the
synovial fluid from temporomandibular disorder patients.
Desferrioxamine (DFO), an iron chelator, strongly depressed the DMPO-OH
signal intensity in the synovial fluid from patients with
temporomandibular disorders. We successfully demonstrated ROS-induced
oxidative stress in the synovial fluid from temporomandibular disorder
patients. ROS generation in the temporomandibular joint could lead to
exacerbation of inflammation and activation of cartilage matrix
degrading enzymes that proceed to degenerative change of the
temporomandibular joint. Thus, iron-dependent generation of HO( *)
might have a crucial role in the pathogenesis of temporomandibular
disorders.
PMID: 15720828 [PubMed - in process]
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