---
Ankylosing spondylitis / Oxidative stress
Ankylosing spondylitis / Oxidative stress -- Posted by ironjustice@aol.com on 02-27-05 12:47
Rheumatology (Oxford). 2004 Oct;43(10):1235-9. Epub 2004 Aug 03.
Related Articles, Links
Protein oxidation status in patients with ankylosing spondylitis.
Yazici C, Kose K, Calis M, Kuzuguden S, Kirnap M.
Department of Biochemistry, Faculty of Medicine, Erciyes University,
Kayseri, Turkey. yazici@erciyes.edu.tr
OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory
disease with unknown aetiology. Since various functions of neutrophils
are increased in AS, neutrophil activation-mediated oxidative stress
may have an important role in the pathogenesis of AS. Therefore, the
importance of neutrophil activation as the main source of oxidative
stress was investigated in patients with AS. METHODS: Forty-one
patients with AS, divided into active and inactive groups according to
their CRP and ESR, and 30 healthy volunteers were entered into the
study. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)
and the visual analogue scale (VAS) were also used in all patients
before the study. In addition, the patients were evaluated according to
spinal involvement and peripheral involvement. Plasma myeloperoxidase
(MPO) activity, representing neutrophil activation, and oxidative
stress biomarkers, such as advanced oxidation protein products (AOPP)
and thiol levels, were measured. RESULTS: There were significant
increases in plasma MPO activity and AOPP but decreases in thiol levels
in the total AS patient group and in the subgroups, compared with
controls. All parameters, except thiol, were higher in active and
peripheral involvement groups than in the inactive and spinal patients,
respectively; but the highest levels were observed in the peripheral
subgroup. In addition, AOPP was found to be positively correlated with
ESR, CRP and BASDAI in the total patient group and with white blood
cell and neutrophil count in the peripheral involvement subgroup.
BASDAI was positively correlated with VAS, ESR and CRP; but MPO was
negatively correlated with thiol/albumin ratio, both in total and
active AS patients. Negative correlations were also observed between
albumin and ESR, and between CRP and neutrophil counts in the
peripheral subgroup. CONCLUSIONS: This is the first study suggesting
neutrophil-MPO-hypochlorous acid-mediated AOPP formation in AS.
Therefore, active neutrophils and chlorinated oxidants of neutrophil
origin may be considered to be important factors in the pathogenesis of
AS which are related to oxidative stress, notably protein oxidation.
PMID: 15292529 [PubMed - indexed for MEDLINE]
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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Re: Ankylosing spondylitis / Oxidative stress -- Posted by spodosaurus on 02-28-05 09:08
ironjustice@aol.com wrote:
That had nothing to do with iron, you disgusting little hygenically
challenged child :-)
Re: Ankylosing spondylitis / Oxidative stress -- Posted by firechief on 02-28-05 19:29
>
Thank you for eliminating the drivel no one wants
to read in the first instance....and especially in a
quote from this returd.....retard.
> That had nothing to do with iron, you disgusting
> little hygenically challenged child :-)
Oh come on. Tell us how you really fell about
numbnutz.
Coincidence? In the waiting room of the lab
today I read in Preventative Medicine how we
indeed need iron to produce blood cells. We
also need zinc (most common sources include
beef/oysters/pork/chicken) to prevent dwarfism,
immunological abnormalities, developmental
disorders of fetus. Zinc improves healing of
wounds and affects taste (for the better).
... I ran today....the ice cream truck was going 40MPH.
Re: Ankylosing spondylitis / Oxidative stress -- Posted by Mike-UK on 03-02-05 17:05
On Mon, 28 Feb 2005, firechief wrote:
> >
>
> Thank you for eliminating the drivel no one wants
> to read in the first instance....and especially in a
> quote from this returd.....retard.
Ya got it right first time. :)
http://tinyurl.com/6vwgs
could be of interest...
--
---------------------------
http://tinyurl.com/4872c
Have a nice day, it really does do you good! :)
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