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Oxidative stress / rust / rheumatoid arthritis
Oxidative stress / rust / rheumatoid arthritis -- Posted by ironjustice@aol.com on 06-22-05 02:20
<>
Significantly higher serum MDA and AOPP levels were detected in RA
patients. Serum AOPP and MDA levels can reflect the oxidation status in
RA patients.
<>
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun;25(6):749-50. Related Articles,
Links
[Determination of oxidation-reduction level in patients with rheumatoid
arthritis.]
[Article in Chinese]
Cai WC, Wang H, Li RQ, Gao L.
Department of Clinical Laboratory, Yuebei People's Hospital, Shaoguan
512026, China.
OBJECTIVE: To examine the oxidation or reduction products in patients
with rheumatism arthritis (RA), and investigate the relationship
between oxidation or reduction products and occurrence and development
of RA. METHODS: The serum levels of total ascorbic acid (TAA),
dehydroascorbic acid (DHAA)/TAA, vitamin E, advanced oxidation protein
products (AOPP) and malondialdehyde (MDA) were detected by
high-performance liquid chromatography with electrochemical detection
in 83 RA patients and 30 healthy adults. Correlation analysis of AOPP,
MDA and hs-CRP was performed. RESULTS: Compared with normal control
group, significantly higher serum MDA, DHAA/TAA, and AOPP levels were
detected in RA patients (P<0.05), but vitamine E showed no significant
difference (P<0.05). Linear regression analysis showed that MDA
(P<0.01) was positively but AOPP (P>0.05) negatively correlated to
hs-CRP. CONCLUSIONS: Oxidation or reduction products in serum of RA
patients increases significantly, which may be an important mechanism
for the occurrence and development of RA. Serum AOPP and MDA levels can
reflect the oxidation status in RA patients.
PMID: 15958331 [PubMed - in process]
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