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--- Tetracycline Antibiotic for Osteoarthritis
ironjustice@aol.com wrote: > Promise of Tetracycline Antibiotic for Osteoarthritis > 14 Jul 2005 > > > Study Shows Effectiveness of Doxycycline in Slowing Disease > Progression. A tetracycline antibiotic, doxycycline, has been > successfully used to treat a wide-range of bacterial infections. In > addition to its effects as an antibiotic, doxycycline has other actions > as a drug and, in laboratory studies with animals and with human > tissue, can inhibit the degradation of cartilage in a way that could be > useful for the treatment of osteoarthritis (OA). OA is a common form of > arthritis associated with pain and disability related to the breakdown > of cartilage, the tissue in the joint that absorbs shock and promotes > smooth movement. > > On the strength of preclinical evidence, a team of rheumatologists > affiliated with six clinical research centers across the United States > conducted the first long-term clinical trial to determine the benefits > of doxycycline in the treatment of OA-particularly, OA of the knee. > Their findings, featured in the July 2005 issue of Arthritis & > Rheumatism ( http://www.interscience.wiley.com/journal/arthritis), > suggest that doxycycline may slow the progression of joint damage and > point to the need for further research into the drug's effect on the > signs and symptoms of this disease. > > For the trial, the team recruited 431 overweight women between the ages > of 45 and 64 with moderately advanced OA in one knee. The subjects were > randomly assigned to receive either 100 milligrams of doxycycline or a > placebo twice a day for 30 months. At baseline, the 2 treatment groups > were roughly equal with respect to all demographic variables, body mass > index, and types of drugs taken for pain, as well as for the x-ray > severity of OA in the affected knee and the level of knee pain and > functional impairment. OA progression was assessed by measuring joint > space narrowing in the medial tibiofemoral compartment through X-rays > obtained at baseline, 16 months and 30 months. Severity of joint pain > was assessed every 6 months after a washout period of all nonsteroidal > anti-inflammatory drugs (NSAIDs) and analgesics. > > 71 percent of the subjects completed the treatment protocol. > Radiographs were obtained from 85 percent of all subjects at 30 months. > After 16 months of treatment, the mean loss of joint space width in the > diseased knee in the doxycycline group was 40 percent less than in the > placebo group. After 30 months, it was 33 percent less. Yet, despite > significantly slowing disease progression, d oxycycline did not reduce > the severity of joint pain. However, mean pain scores at baseline were > low in both treatment groups, leaving only limited opportunity to > demonstrate improvement in joint pain. On the other hand, the drug > significantly reduced the frequency with which subjects reported > increases in knee pain 20 percent or greater than the level of pain > they had at their previous semi-annual visit. > > Notably, doxycycline seemed to have no effect on joint space narrowing > or pain in the relatively disease-free knee. In both knees in both > treatment groups, the rate of joint space narrowing was more than twice > as rapid in subjects who reported frequent increases in pain than in > those with a stable pain score. "Joint pain may serve as an indicator > of synovitis that leads to cartilage destruction," observes the > study's leading author, Kenneth D. Brandt, M.D. > > Throughout the trial, fewer than 5 percent of all subjects reported > side effects. In general, doxycycline seemed to be well tolerated. > Subjects in the active treatment group experienced the unexpected side > benefits of fewer urinary tract and upper respiratory tract infections > than their placebo counterparts. > > In conclusion, in this study, doxcycyline showed benefits in slowing > the rate of joint space narrowing in knees with established OA. Whether > this drug has any value in the early treatment and symptomatic > management of OA, however, will require further investigation. > > Article : "Effects of Doxycyline on Progression of Osteoarthritis: > Results of a Randomized, Placebo-Controlled, Double-Blind Trial," > Kenneth D. Brandt, Steven A. Mazzuca, Barry P. Katz, Kathleen A. Lane, > Kenneth A. Buckwalter, David E. Yocum, Frederick Wolfe, Thomas J. > Schnitzer, Larry W. Moreland, Susan Manzi, John D. Bradley, Leena > Sharma, Chester V. Oddis, Steven T. Hugenberg, and Louis W. Heck, > Arthritis & Rheumatism , July 2005; 52:7; pp. 2015-2025. Article is > available via Wiley InterScience at > interscience.wiley.com/journal/arthritis. > > http://www.rheumatology.org > > > -------------------------------------------------------------------------------- > > Antimicrob Agents Chemother. 2000 Mar;44(3):763-6. Related Articles, > Links > > > Iron-chelating activity of tetracyclines and its impact on the > susceptibility of Actinobacillus actinomycetemcomitans to these > antibiotics. > > Grenier D, Huot MP, Mayrand D. > > Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, > Quebec, Canada. Daniel.Grenier@greb.ulaval.ca > > Three tetracyclines (tetracycline, doxycycline, and minocycline) were > found to possess iron-chelating activity in a colorimetric siderophore > assay. Determination of MICs indicated that the activity of doxycycline > against the periodontopathogen Actinobacillus actinomycetemcomitans was > only slightly influenced by the presence of an excess of iron that > likely saturates the antibiotic. On the other hand, the MICs of > doxycycline and minocycline were significantly lower for A. > actinomycetemcomitans cultivated under iron-poor conditions than under > iron-rich conditions. > > PMID: 10681353 [PubMed - indexed for MEDLINE] > > -------------------------------------------------------------------------------- > > Who loves ya. > Tom > > Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com > Man Is A Herbivore! > http://pages.ivillage.com/ironjustice/manisaherbivore > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking Yeah. Thats great. Antibiotics are horrible for your body. Better off to ingest rat poison for pain.
The article is kind of placed .. TO .. demonstrate the EFFECTIVENESS .. of .. TARGETING .. iron .. i-r-o-n .. Pretty much the same as THIS .. iron binder .. lactoferrin .. a .. natural .. iron binder .. Clin Med Res. 2005 May;3(2):93-101. Related Articles, Links Lactoferrin - a novel bone growth factor. Naot D, Grey A, Reid IR, Cornish J. Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand. . d.naot@auckland.ac.nz. Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. It is present in breast milk, in epithelial secretions, and in the secondary granules of neutrophils. In healthy subjects lactoferrin circulates at concentrations of 2-7 x 10(-6) g/ml. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. Recently, we have shown that lactoferrin can also promote bone growth. At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal. Lactoferrin also affects osteoclast formation and, in murine bone marrow culture, lactoferrin potently inhibits osteoclastogenesis. In vivo, local injection of lactoferrin above the hemicalvaria of adult mice results in substantial increases in the dynamic histomorphometric indices of bone formation and bone area. The mitogenic effect of lactoferrin in osteoblast-like cells is mediated mainly through LRP1, a member of the family of low-density lipoprotein receptor-related proteins that are primarily known as endocytic receptors. Using confocal laser scanning microscopy, we demonstrated that fluorescently labeled lactoferrin is endocytosed and can be visualized in the cytoplasm of primary osteoblastic cells. Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin. We conclude that lactoferrin may have a physiological role in bone growth and healing, and a potential therapeutic role as an anabolic factor in osteoporosis. PMID: 16012127 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
ironjustice@aol.com wrote: > The article is kind of placed .. TO .. demonstrate the EFFECTIVENESS .. > of .. TARGETING .. iron .. i-r-o-n .. 14 > > Pretty much the same as THIS .. iron binder .. lactoferrin .. a .. > natural .. iron binder .. 12 Did Captain Kirk even do 18 pauses in single session, or are you just showing off? -- spammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/
news:1123172135.862318.254750@g44g2000cwa.googlegroups.com... > The article is kind of placed .. TO .. demonstrate the EFFECTIVENESS .. > of .. TARGETING .. iron .. i-r-o-n .. Just a note for new people reading this newsgroup. This troll does not post here all the time and his use of old and new information is always to support his mental problems and view of life itself. I am not saying that every now and then there is some truth and interesting new information gets in his/her posts by accident(IMO). Again,,, (IMO) if you read his/her posts,,, do so with a ready hand full of salt. Harv Ps A great many people have him killfiled and my apologies to those people for replying to one of his posts. Related Discussion: Sleep Apnea Syndrome (7 posts) Re: Ayurvedic woes raise new questions about drug agency oversight (1 posts) Max 3 years to $3M :: No Joke! (1 posts) New All Natural Vitamin (1 posts) Top Discussions From Our Archives Holistic Drug and Alcohol Rehabiltation Program that Works! Newer beta-blocker seen safer for diabetics Other Discussion Categories Diabetes Symptoms Health Care Policy Health Care Providers HMO Arthritis Symptoms
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