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bone growth / lactoferrin / iron
bone growth / lactoferrin / iron -- Posted by doe on 05-29-04 11:34
Lactoferrin is an iron binder produced in our own bodies.
<>
Lactoferrin is a potential therapeutic target in bone disorders such as
osteoporosis and possibly an important physiological regulator of bone growth.
<>
Endocrinology. 2004 May 27 [Epub ahead of print] Related Articles, Links
Lactoferrin Is A Potent Regulator Of Bone Cell Activity And Increases Bone
Formation In Vivo.
Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, Watson M, Lin JM,
Tong P, Chen Q, Chan VA, Reid HE, Fazzalari N, Baker HM, Baker EN, Haggarty NW,
Grey AB, Reid IR.
Department of Medicine, University of Auckland, Auckland, New Zealand; Fonterra
Research Centre, Palmerston North, New Zealand; Institute of Medical and
Veterinary Science, Adelaide, Australia; School of Biological Sciences,
University of Auckland.
Lactoferrin is an iron-binding glycoprotein present in epithelial secretions,
such as milk, and in the secondary granules of neutrophils. We found it to be
present in fractions of milk protein that stimulated osteoblast growth, so
assessed its effects on bone cell function. Lactoferrin produced large,
dose-related increases in thymidine incorporation in primary or cell-line
cultures of human or rat osteoblast-like cells, at physiological concentrations
(1-100 micro g/ mL). Maximal stimulation was 5-fold above control. Lactoferrin
also increased osteoblast differentiation, and reduced osteoblast apoptosis by
up to 50-70%. Similarly lactoferrin stimulated proliferation of primary
chondrocytes. Purified, recombinant, human or bovine lactoferrins had similar
potencies. In mouse bone-marrow cultures, osteoclastogenesis was
dose-dependently decreased, and was completely arrested by lactoferrin 100
micro g/mL, associated with decreased expression of RANKL. In contrast,
lactoferrin had no effect on bone resorption by isolated mature osteoclasts.
Lactoferrin was administered over calvariae of adult mice for 5 days. New bone
formation, assessed using fluorochrome labels, was increased 4-fold by a 4 mg
dose of lactoferrin. Thus lactoferrin has powerful anabolic, differentiating
and anti-apoptotic effects on osteoblasts, and inhibits osteoclastogenesis.
Lactoferrin is a potential therapeutic target in bone disorders such as
osteoporosis and possibly an important physiological regulator of bone growth.
PMID: 15166119 [PubMed - as supplied by publisher]
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