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--- Iron induced osteopenia
Sorry bonehead, no iron overloaded rats here. Please drive through. Or you could entertain us with your Captain Kirk impressions some more. Up to you. Cheers! -- spammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/
I wonder why an iron binder like lactoferrin would promote bone .. growth .. Clin Med Res. 2005 May;3(2):93-101. Related Articles, Links Lactoferrin - a novel bone growth factor. Naot D, Grey A, Reid IR, Cornish J. Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand. . d.naot@auckland.ac.nz. Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. It is present in breast milk, in epithelial secretions, and in the secondary granules of neutrophils. In healthy subjects lactoferrin circulates at concentrations of 2-7 x 10(-6) g/ml. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. Recently, we have shown that lactoferrin can also promote bone growth. At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal. Lactoferrin also affects osteoclast formation and, in murine bone marrow culture, lactoferrin potently inhibits osteoclastogenesis. In vivo, local injection of lactoferrin above the hemicalvaria of adult mice results in substantial increases in the dynamic histomorphometric indices of bone formation and bone area. The mitogenic effect of lactoferrin in osteoblast-like cells is mediated mainly through LRP1, a member of the family of low-density lipoprotein receptor-related proteins that are primarily known as endocytic receptors. Using confocal laser scanning microscopy, we demonstrated that fluorescently labeled lactoferrin is endocytosed and can be visualized in the cytoplasm of primary osteoblastic cells. Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin. We conclude that lactoferrin may have a physiological role in bone growth and healing, and a potential therapeutic role as an anabolic factor in osteoporosis. PMID: 16012127 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
ironjustice@aol.com wrote: > I wonder why an iron binder like lactoferrin would promote bone .. > growth .. > Absolutely nothing to do with its iron binding properties: "At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal" But you'd know this if you had more than a year 10 education. Now it's time to start with the Captain Kirk impressions. C'mon, you know you want to! Cheers! -- spammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/
>>Absolutely nothing to do with its iron binding properties: "At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal" But you'd know this if you had more than a year 10 education. Now it's time to start with the Captain Kirk impressions. C'mon, you know you want to! << Yep .. nothing to do with its' iron binding properties .. If using iron binders like lactoferrin stimulate bone growth .. and using iron reducing .. induces bone growth .. Then .. iron .. targeting .. induces .. bone .. growth .. YOU .. are stupid .. How IS your melting skeleton .. there .. spondy ... STILL getting the iron removed .. ? Quit .. that .. It .. is .. waste of time .... Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
ironjustice@aol.com wrote: >>>Absolutely nothing to do with its iron binding properties: > > "At physiological concentrations, > lactoferrin potently stimulates the proliferation and differentiation > of primary osteoblasts and also acts as a survival factor inhibiting > apoptosis induced by serum withdrawal" > > But you'd know this if you had more than a year 10 education. Now it's > time to start with the Captain Kirk impressions. C'mon, you know you > want to! > << > > Yep .. nothing to do with its' iron binding properties .. 4 > > If using iron binders like lactoferrin stimulate bone growth .. and > using iron reducing .. induces bone growth .. 6 > > Then .. iron .. targeting .. induces .. bone .. growth .. > > YOU .. are stupid .. 16 (btw- it's not iron targetting, it's a completely different mechanism: if you had more than a year 10 education you'd have better english comprehension) > > How IS your melting skeleton .. there .. spondy ... 7 (you used an odd number of full stops, you're slipping!) > > STILL getting the iron removed .. ? 2 > > Quit .. that .. > 4 > It .. is .. waste of time .... 8 > > Who envies ya? > Tom! > Tom touches himself compulsively! http://tom-has-issues.7h.com > Man Is Tom A Bore! > http://pages.ivillage.com/compulsive-masturbator/stickykeyboard > I SEE DEAD PEOPLE WALKING > http://pages.ivillage.com/off-my-meds/too-much-TV > -- spammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ 1 2 Next » Related Discussion: Re: rebuild the cuntface of the spamming scammer matt parker http://tinyurl.com/452ch (1 posts) O2 Detox Foot Spas (1 posts) Chinese Energetic Method and Homeopathy for Arthritis & Rheumatism (1 posts) New Medical technology (5 posts) Top Discussions From Our Archives Very good prices on ultram!!!! Many Seniors Skipping their Medications Re: Apologies for "Mad" Bill Pal m er's annoying usenet behaviour. Other Discussion Categories Diabetes Symptoms Health Care Policy
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