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Reducing bone loss due to iron / Toctrienol versus Tocopherol
Reducing bone loss due to iron / Toctrienol versus Tocopherol -- Posted by ironjustice@aol.com on 09-22-05 03:06
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FeNTA were also shown to reduce trabecular bone volume and trabecular
thickness
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TOCOTRIENOL OFFERS BETTER PROTECTION THAN TOCOPHEROL FROM FREE
RADICAL-INDUCED DAMAGE OF RAT BONE.
Ahmad N, Khalid B, Luke D, Ima Nirwana S
Clin Exp Pharmacol Physiol. 2005 Sep ; 32(9): 761-770
1=2E Free radicals generated by ferric nitrilotriacetate (FeNTA) can
activate osteoclastic activity and this is associated with elevation of
the bone resorbing cytokines interleukin (IL)-1 and IL-6. In the
present study, we investigated the effects of 2 mg/kg FeNTA (2 mg
iron/kg) on the levels of serum IL-1 and IL-6 with or without
supplementation with a palm oil tocotrienol mixture or alpha-tocopherol
acetate in Wistar rats. 2. The FeNTA was found to elevate levels of
IL-1 and IL-6. Only the palm oil tocotrienol mixture at doses of 60 and
100 mg/kg was able to prevent FeNTA-induced increases in IL-1 (P <
0=2E01). Both the palm oil tocotrienol mixture and alpha-tocopherol
acetate, at doses of 30, 60 and 100 mg/kg, were able to reduce
FeNTA-induced increases in IL-6 (P < 0.05). Therefore, the palm oil
tocotrienol mixture was better than pure alpha-tocopherol acetate in
protecting bone against FeNTA (free radical)-induced elevation of
bone-resorbing cytokines. 3. Supplementation with the palm oil
tocotrienol mixture or alpha-tocopherol acetate at 100 mg/kg restored
the reduction in serum osteocalcin levels due to ageing, as seen in the
saline (control) group (P < 0.05). All doses of the palm oil
tocotrienol mixture decreased urine deoxypyridinoline cross-link (DPD)
significantly compared with the control group, whereas a trend for
decreased urine DPD was only seen for doses of 60 mg/kg onwards of
alpha-tocopherol acetate (P < 0.05). 4. Bone histomorphometric analyses
have shown that FeNTA injections significantly lowered mean osteoblast
number (P < 0.001) and the bone formation rate (P < 0.001), but raised
osteoclast number (P < 0.05) and the ratio of eroded surface/bone
surface (P < 0.001) compared with the saline (control) group.
Supplementation with 100 mg/kg palm oil tocotrienol mixture was able to
prevent all these FeNTA-induced changes, but a similar dose of
alpha-tocopherol acetate was found to be effective only for mean
osteoclast number. Injections of FeNTA were also shown to reduce
trabecular bone volume (P < 0.001) and trabecular thickness (P < 0.05),
whereas only supplementation with 100 mg/kg palm oil tocotrienol
mixture was able to prevent these FeNTA-induced changes.
Abstract =B7 PubMed =B7 FullText =B7 SFX =B7 GS =B7 Order =B7 Clip =B7
Citation =B7 BibTeX =B7 Related =B7 TouchGraph =B7 Scopus =B7 References =
=B7
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Tom
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Re: Reducing bone loss due to iron / Toctrienol versus Tocopherol -- Posted by spodosaurus on 09-22-05 03:18
Hey Tommah,
You want to eat 100mg/kg of palm oil a day? Say someone like you, who
weighs in at about 70 kg of pasty blubber, really likes palm oil. That
would mean you'd have to eat 7kg per day of palm oil. Enjoy, you oily
turd! Oh, and don't forget in order to have any beneficial effect,
you're going to have to eat lots of iron along with it to make sure you
have something to provide a beneficial effect against :-)
Cheers!
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