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Osteoporosis / oxidative stress
Osteoporosis / oxidative stress -- Posted by ironjustice@aol.com on 09-23-05 03:07
Clin Exp Rheumatol. 2005 Sep-Oct;23(5):689-92. Related Articles, Links
Is there a role of free oxygen radicals in primary male osteoporosis?
Yalin S, Bagis S, Polat G, Dogruer N, Cenk Aksit S, Hatungil R, Erdogan
C.
Department of Biochemistry, Mersin University Pharmacy School, Mersin,
Turkey. syalin01@hotmail.com
OBJECTIVE: There is not enough evidence about the relationship between
free radicals and male osteoporosis. In this study we investigated the
role of free oxygen radicals and antioxidants on male osteoporosis in
31 male patients with primary osteoporosis and 21 subjects as controls.
METHODS: Bone mineral densities (BMD) of the lumbar and femoral neck
region were evaluated using dual energy X-ray absorbsiometry. Serum
malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide
dismutase (SOD) and glutathione peroxidase (GPx) activities were
measured by analytical methods. In addition, serum osteocalcine and C
telopeptide levels were determined to evaluate bone turnover MDA and NO
levels and SOD activity were significantly increased (p < 0.05) in
osteoporotic males. RESULTS: There was a negative correlation between
SOD and lumbar BMD levels (r= -0.328; p = 0.021). The same trend was
observed between NO and lumbar BMD (r = -0.473; p = 0.001) and femoral
neck BMD values (r = -0.540; p = 0.000). There was no significant
correlation between free radical levels and bone turnover markers.
CONCLUSION: The data indicate an increase in free oxygen radical
levels. As a result, antioxidant defenses would compromise in primary
male osteoporotic patients. Therefore, it may be suggested that
oxidative stress plays an important role in the pathophysiology of
primary male osteoporosis.
PMID: 16173248 [PubMed - in process]
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