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Arthritis / iron
Arthritis / iron -- Posted by doe on 06-10-04 07:04
<>
Iron induced the expression of mdm2 by normal human synovial cells
approximately 8-fold.
Changes induced by IRON in the blood may be the BASIS of the increase in cell
proliferation and the development of hemophilic synovitis
<>
Blood. 2004 Jun 1 [Epub ahead of print] Related Articles, Links
Pathobiology of hemophilic synovitis I: Over-expression of mdm2 oncogene.
Hakobyan N, Kazarian T, Jabbar AA, Jabbar KJ, Valentino LA.
Pediatrics- Hematology/Oncology, Rush University Medical Center, Chicago, IL,
USA; Immunology/Microbiology, Rush University, Chicago, IL, USA.
Hemophilia is a genetic disease due to the deficiency of blood coagulation
factor VIII or IX. Bleeding into joints is the most frequent manifestation of
hemophilia. Hemarthrosis results in an inflammatory and proliferative disorder
termed hemophilic synovitis (HS). In time, a debilitating, crippling arthritis,
hemophilic arthropathy develops. Although the clinical sequence of events from
joint bleeding to synovitis to arthropathy are well documented, the
component(s) in blood and the molecular changes responsible for hemophilic
synovitis are not known. Iron has long been suspected to be the culprit but
direct evidence has been lacking. Previously, we showed that iron increased
human synovial cell proliferation and induced c-myc expression. Here we show
that bleeding into a joint in vivo and iron in vitro result in increased
expression of the p53-binding protein, mdm2. Iron induced the expression of
mdm2 by normal human synovial cells approximately 8-fold. In a murine model of
human hemophilia A, hemarthrosis resulted in pathological changes observed in
human hemophilic synovitis and a marked increase in synovial cell
proliferation. Iron, in vitro, induced the expression of mdm2. These molecular
changes induced by iron in the blood may be the basis of the increase in cell
proliferation and the development of hemophilic synovitis.
PMID: 15172967 [PubMed - as supplied by publisher]
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Which may well explain the problem they have found in those with Juvenile
Rheumatoid Arthritis .. INCREASED destruction by introduction of iron ..
EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may hasten joint
deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic children take to
combat concomitant anemia may be hastening the deterioration of their joints,
Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition Research Centre at
Baylor College of Medicine, a Texas team looked at eight children being treated
for juvenile rheumatoid arthritis. The patients, aged five to 15 years,
received an intravenous radioactive tracer dose of iron (0.03 microsievert).
Iron activity in affected joints was monitored on a position/energy-sensitive
gamma counter, while a second machine monitored whole-body iron retention. Iron
deposition was measured two hours post-infusion and again at days seven, 14, 28
and 56.
Anemic
"We found that iron excessively accumulates in arthritic joints and probably
contributes to the chronic damage," said Shypailo. "That puts you between a
rock and a hard place because many of these arthritic kids are anemic and need
iron supplements, which may worsen the disease."
The study found a high level of agreement between the joint data and the
whole-body data, with a greater than 90% retention rate of the infused iron
both in joints and systemically. Furthermore, six of eight patients showed
increased uptake at the affected joints: 165% over the first 30 days compared
with initial uptake at two hours.
The next step, he says, is to see if there is excessive deposition of dietary
iron in arthritic joints.
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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
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