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Diabetic rats exhibit altered triglyceride-rich lipoprotein production
Diabetic rats exhibit altered triglyceride-rich lipoprotein production -- Posted by Gumbo on 10-24-04 12:40
ADA Comments:
Zucker diabetic fatty rats exhibit altered triglyceride-rich lipoprotein
production. "Triglyceride-rich lipoprotein (TRL) production was studied in
Zucker diabetic fatty (ZDF) rats, a model of insulin-resistant type 2
diabetes progression. TRL production was measured in vivo by blocking
catabolism with Triton WR-1339. Ten-week ZDF rats are hyperinsulinemic with
increased TRL production [both triglyceride and apolipoprotein B (apoB)].
Twenty-week ZDF rats are insulinopenic, and TRL production is similar to
lean controls. Insulin infusion suppresses glucose and free fatty acids in
10- and 20-week ZDF rats," investigators in the United States report.
"Increased TRL production is not reduced by insulin in 10-week rats;
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19-AUG-2004
Diabetic rats exhibit altered triglyceride-rich lipoprotein production
Zucker diabetic fatty rats exhibit altered triglyceride-rich lipoprotein
production.
"Triglyceride-rich lipoprotein (TRL) production was studied in Zucker
diabetic fatty (ZDF) rats, a model of insulin-resistant type 2 diabetes
progression. TRL production was measured in vivo by blocking catabolism with
Triton WR-1339. Ten-week ZDF rats are hyperinsulinemic with increased TRL
production [both triglyceride and apolipoprotein B (apoB)]. Twenty-week ZDF
rats are insulinopenic, and TRL production is similar to lean controls.
Insulin infusion suppresses glucose and free fatty acids in 10- and 20-week
ZDF rats," investigators in the United States report.
"Increased TRL production is not reduced by insulin in 10-week rats;
however, at 20 weeks, TRL production is suppressed by insulin," said Doru V.
Chirieac and colleagues at the University of Rochester. "In vitro studies
with hepatocytes derived from 10-week ZDF rats showed minimal insulin dose
effects on apoB secretion compared with the response and sensitivity of
hepatocytes derived from 20-week ZDF and control lean rats. Hepatic sterol
regulatory-binding protein (SREBP)-1c mRNA levels are increased at 10 weeks
but return to control levels at 20 weeks. ApoB mRNA levels are similar to
lean controls at 10 and 20 weeks."
The scientists concluded, "The following two mechanisms for
hypertriglyceridemia associated with hyperinsulinemia are suggested:
increased TRL synthesis and loss of TRL suppression. Increased triglyceride
production in hyperinsulinemic rats likely relates to increased expression
of SREBP-1c, whereas increased apoB production involves posttranscriptional
processes."
Chirieac and associates published their study in the American Journal of
Physiology - Endocrinology and Metabolism (Altered triglyceride-rich
lipoprotein production in Zucker diabetic fatty rats. Amer J
Physiol-Endocrinol Met, 2004;287(1):E42-E49).
For additional information, contact Charles E. Sparks, Department of
Pathology and Laboratory Medicine, University of Rochester School of
Medicine and Dentistry, PO Box 626, 601 Elmwood Avenue, Rochester, NY 14642,
USA. E-mail: Charles_Sparks@urmc.rochester.edu.
The publisher of the American Journal of Physiology - Endocrinology and
Metabolism can be contacted at: American Physiological Society, 9650
Rockville Pike, Bethesda, MD 20814, USA.
The information in this article comes under the major subject areas of Lipid
Studies, Diabetes Pathogenesis, Obesity and Diabetes, and Endocrinology.
This article was prepared by Biotech Week editors from staff and other
reports. Copyright 2004, Biotech Week via NewsRx.com & NewsRx.net.
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