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New Diabetes Drug Doesn't Increase Weight
New Diabetes Drug Doesn't Increase Weight -- Posted by Gumbo on 10-24-04 14:43
New Diabetes Drug Doesn't Increase Weight
NEW YORK (Reuters Health) - Insulin, Glucotrol, and drugs like Avandia and
Actos are all effective treatments for diabetes, but they can produce weight
gain. In contrast, an experimental drug called liraglutide seems to control
sugar levels without this frustrating side effect, Dutch researchers report.
As reported in the journal Diabetes Care, Dr. Arne Astrup, from The Royal
Veterinary and Agricultural University in Frederiksberg, and colleagues
studied the effects of liraglutide in 33 patients with type 2 diabetes. The
patients were randomly assigned to receive a daily infection of liraglutide
or inactive "placebo" for 8 weeks.
Compared with placebo, liraglutide improved blood sugar control without
inducing weight gain. In fact, patients treated with the drug were slightly
more likely to experience a drop in total body fat.
This suggests to the team that, at higher doses and for longer periods of
time, "liraglutide actually may have the potential to induce weight loss." A
significant drop in body weight was observed in a liraglutide trial reported
in June.
Liraglutide had no effect on appetite or food intake. Adverse effects were
"mainly mild and related to the gastrointestinal system," the team also
reports, and there were no episodes of abnormally low sugar levels during
the trial.
Astrup and colleagues call for further studies to better understand "the
weight profile of liraglutide."
SOURCE: Diabetes Care,
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