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Three-Drug Plan for Glycemic Control
Three-Drug Plan for Glycemic Control -- Posted by Gumbo on 10-30-04 06:38
Three-Drug Plan for Glycemic Control
Originally Published:20041001.
People with type 2 diabetes can improve glycemic control with triple drug
therapy, according to a new study. Taking insulin, metformin, and
troglitazone improves glycemic control and lowers daily insulin needs
without causing weight gain, according to study findings.
Researchers compared therapy with insulin and metformin or insulin and
troglitazone to therapy with all three drugs in 28 people with type 2
diabetes. Patients first received one of the dual drug therapies for 4
months. Then all patients followed the three-drug plan for 4 months.
Although glycemic control improved with the dual drug therapies, it improved
even more with triple drug therapy. After 4 months of triple drug therapy,
none of the patients had a hemoglobin AIC level above 7%, and more than half
had a hemoglobin AIC level below 6%. Patients also needed significantly less
insulin while on the triple drug regimen.
Patients who initially received insulin and troglitazone gained 4.4 kg
(about 10 pounds), but didn't gain more weight when they added metformin.
Patients who initially took insulin and metformin didn't gain weight during
either course of therapy.
In people who took insulin and troglitazone, total cholesterol and
low-density lipoprotein cholesterol significantly increased during the 4
months of therapy. Neither group experienced significant changes in
cholesterol levels while taking the triple drug therapy.
Though troglitazone has been taken off the market in the United States,
other thiazolidinedione drugs, such as rosiglitazone (Avandia) are
available. Researchers say their findings suggest that therapy with insulin
and both classes of insulin sensitizers helps improve glycemic control.
Source: "Improved Glycemic Control without Weight Gain Using Triple Therapy
in Type 2 Diabetes," Diabetes Care, S Strowig, et al., July 2004.
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