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Blood pressure drugs not linked to diabetes
Blood pressure drugs not linked to diabetes -- Posted by Gumbo on 10-31-04 05:10
Blood pressure drugs not linked to diabetes
Oct 13 (Reuters Health) - There is some evidence that various types of drugs
used to treat high blood pressure could hasten or impede the development of
type 2 diabetes, but the latest findings don't support that idea.
According to the results of a study in the medical journal Diabetes Care,
the risk of type 2 diabetes does not appear to be increased or decreased in
elderly hypertensive patients who use any of the major classes of blood
pressure-lowering medications.
Dr. Raj Padwal, of the University of Alberta Hospital, Canada, and
colleagues examined the occurrence of type 2 diabetes among previously
untreated elderly patients who started treatment for high blood pressure.
A total of nearly 40,000 subjects were on ACE inhibitors, some 20,000 were
taking beta-blockers, and about 20,000 were given calcium channel blockers.
More than half of the subjects (53 percent) were excluded from the analysis
because of medication discontinuation, and 17 percent were dropped from the
study after another medication was added.
The team found that neither ACE inhibitors nor beta- blockers were
associated with a significant difference in type 2 diabetes incidence
compared to that seen with calcium channel blockers.
Similar results were obtained when a sub-analysis looked at patients who
were taking a diuretic in addition to another drug.
Padwal's group thinks diabetes should not be a concern when high blood
pressure is being treated.
"We suggest that clinicians guide their choice of initial antihypertensive
therapy on the basis of more established factors, such as the available
evidence regarding efficacy, economic considerations, and the presence of
comorbid medical conditions," the researchers conclude.
SOURCE: Diabetes Care, October 2004.
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