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New Discovery Could Help Prevent Diabetic Complications
New Discovery Could Help Prevent Diabetic Complications -- Posted by Gumbo on 11-02-04 18:35
New Discovery Could Help Prevent Diabetic Complications
A new study sheds light on the response to infection in people with type 2
diabetes.
Findings from this study revealed that controlling a specific protein
produced by the body, known as a cytokine, reduces the expression of other
molecules and helps control inflammation. This is significant because many
complications associated with diabetes trigger an inflammatory response.
Tumor necrosis factor (TNF), a type of cytokine, can cause inflammation and
damage in soft tissue infections, bite wounds and in periodontal disease. In
a recent study published in the Journal of Investigative Dermatology, two
groups of lab mice, one normal, the other diabetic, were injected with
anaerobic bacteria, a germ present in "approximately one-third of bite
wounds and ... associated with the formation of abscesses and with
relatively serious infections," to determine how type 2 diabetes affects the
inflammatory response in surrounding tissue.
Results from the tests demonstrated that the presence of diabetes prolongs
inflammation. Following infection, the normal mice were able to rapidly
resolve the ensuing inflammation within 3 days whereas the diabetic mice
could not.
"It may be particularly important in diabetics to consider the impact that
prolonged inflammation might have on the course of events," said
contributing author Dr. Dana T. Graves.
According to the study, diabetics are particularly susceptible to the
detrimental effects of infection associated with inflammatory cytokines.
Further, inflammation can often be a precursor to complications such as
cardiovascular disease and poor wound healing. Graves concluded, "If excess
TNF in diabetics is inhibited, the tendency for prolonged inflammation is
reduced" (Naguib G, Al-Mashat H, Desta T, et al., Diabetes prolongs the
inflammatory response to a bacterial stimulus through cytokine
dysregulation. J Invest Dermatol, 2004;123(1):87-92). This article was
prepared by Diabetes Week editors from staff and other reports. Copyright
2004, Diabetes Week via NewsRx.com & NewsRx.net.
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