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Forecast: Diabetes May no Longer be a Bitter Pill to Swallow
Forecast: Diabetes May no Longer be a Bitter Pill to Swallow -- Posted by Gumbo on 11-05-04 17:50
Forecast: Diabetes May no Longer be a Bitter Pill to Swallow
People with diabetes may soon be able to swap their tablets for creams and
ointments according to new research launched at the British Pharmaceutical
Conference.
This news is expected to come as a relief for type 2 diabetes patients who
are routinely treated with oral hypoglycemic drugs to lower their blood
glucose levels. These can cause severe gastrointestinal side effects, such
as nausea, vomiting, and diarrhea.
Because of the unpleasant side-effects of these diabetes drugs, some
patients are reluctant to take their medicines. Researchers in Egypt believe
that giving these drugs through the skin could improve the situation,
helping reduce the risk of the long-term vascular complications of diabetes.
Professor Hussein Ammar, from the department of pharmaceutical sciences at
the National Research Centre in Cairo, Egypt, said that his team has been
working with a drug called glipizide, a commonly used hypoglycemic agent.
They prepared various ointment and cream formulations and then tested
whether the drug was able to pass through the skin to exert its therapeutic
effect.
The results showed that 2 formulations were shown to have a sustained effect
on glucose levels for around 48 hours when applied to rats. "The results
lead us to believe that topical administration is possible," Ammar reported.
He sees value in this type of product. "Ointments, creams, and gels are
acceptable formulations and have the advantages of ease of preparation and
low cost. A trans dermal patch might also be an option."
The long-term complications of diabetes include eye problems, kidney
problems, and cardiovascular disease. These complications are known to be
reduced with strict control of blood glucose levels (glycemic control). The
researchers believe that a topical formulation that provides a steady
release of drug into the blood will help to maintain good glycemic control
and, in turn, might help to reduce the risk of long-term complications. This
article was prepared by Biotech Law Weekly editors from staff and other
reports. Copyright 2004, Biotech Law Weekly via LawRx.com.
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