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Diabetes Contributes to Salivary Gland Dysfunction
Diabetes Contributes to Salivary Gland Dysfunction -- Posted by Gumbo on 11-14-04 19:47
Diabetes Contributes to Salivary Gland Dysfunction
Diabetes mellitus was seen to contribute to salivary gland dysfunction.
Researchers from Portugal "investigated the effects of diabetes mellitus
(types I and II) on human salivary gland function compared to healthy
age-matched controls. The results have shown that both type I and type II
diabetic patients secrete significantly (p < 0.05) less resting and
stimulated saliva compared to healthy age-matched controls (AMC)."
A.D. Mata and colleagues, ISCS-Sul in Monte Caparica, "also found that the
diabetic patients have an increased resting and stimulated salivary protein
concentration compared to healthy participants. However, the secretory
capacity (stimulated minus resting values) was markedly reduced compared to
controls."
"The level of calcium (Ca2+) in the saliva of diabetic patients was
significantly (p 2+), zinc (Zn2+) and potassium (K+) in the saliva of
diabetic patients were significantly (p<0.05) reduced compared to the values
obtained in AMC."
"These results indicate that diabetes mellitus can lead to marked
dysfunction of the secretory capacity of the salivary glands. In these
patients a modified fluid, organic and inorganic salivary secretion may be
responsible for the increased susceptibility to oral infections and impaired
wound healing described by others in the literature," Mata and coauthors
concluded.
Mata and colleagues published their study in Molecular and Cellular
Biochemistry (Effects of diabetes mellitus on salivary secretion and its
composition in the human. Mol Cell Biochem, 2004;261(1):137-142).
For more information, contact A.D. Mata, Institute Super Ciencias Saude Sul,
Department Oral Biology, Campus University Quinta Granja, Monte Caparica,
Portugal.
Publisher contact information for the journal Molecular and Cellular
Biochemistry is: Kluwer Academic Publ, Van Godewijckstraat 30, 3311 Gz
Dordrecht, Netherlands.
The information in this article comes under the major subject areas of
Endocrinology, Otorhinolaryngology and Salivary Glands. This article was
prepared by Biotech Week editors from staff and other reports. Copyright
2004, Biotech Week via NewsRx.com & NewsRx.net.
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