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New Possible Neuropathy Drug
New Possible Neuropathy Drug -- Posted by Gumbo on 11-14-04 19:50
New Possible Neuropathy Drug
Issue 232 Item 2
on Tuesday, November 02 @ 12:47:15 EST
An experimental drug has been shown to combat the underlying cause of nerve
damage that occurs in people with diabetes.
"An effective disease-modifying treatment is on the horizon," says Dr. Vera
Bril of the University of Toronto.
A compound called sorbitol builds up in diabetes, and increased levels of
sorbitol in nerves has been associated with nerve damage in animals, Bril
and her colleagues explain in the medical journal Diabetes Care.
High sorbitol results from increased activity of an enzyme called aldose
reductase, suggesting that treatments to block the enzyme might prevent or
reverse nerve damage.
Bril's team gave patients with diabetic neuropathy a potent inhibitor of
aldose reductase called AS-3201, and measured sorbitol in a nerve in their
calf before and after 12 weeks of treatment.
Compared with the placebo treatment, AS-3201 reduced average nerve sorbitol
concentrations by 65 percent to 84 percent depending on the dosage given,
the researchers report.
"For the first time, we may see disease regression with a disease modifying
treatment," Bril said.
Patients treated with the higher dose of AS-3201 showed improvement in the
velocity of nerve signal conduction, the investigators report, but vibratory
perception threshold and clinical scores did not change during this brief
study.
"There is great hope for the treatment of diabetic sensorimotor
polyneuropathy," she concluded.
Diabetes Care, October 2004.
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