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Atherosclerosis Begins Early in Type 1 Diabetes Patients
Atherosclerosis Begins Early in Type 1 Diabetes Patients -- Posted by Gumbo on 11-14-04 19:51
Atherosclerosis Begins Early in Type 1 Diabetes Patients
on Tuesday, November 02 @ 12:51:37 EST
Study shows that atherosclerosis, begins early and that it relates to
abnormalities of lipids and to diabetes complications.
New study findings provide more evidence that atherosclerosis begins early
in young persons with type 1 diabetes and underscore the need to monitor BP
and lipid levels in adolescents with the disease.
California-based researchers measured carotid artery intima-media thickness
(IMT), a marker of subclinical atherosclerosis, in 142 type 1 diabetics
between 12 and 25 years of age and 87 age-matched non-diabetic controls.
They also measured fasting lipid and homocysteine levels, BP, BMI and degree
of glycemic control in the diabetic subjects.
The mean carotid IMT was greater in diabetic than in non-diabetic subjects
(p = 0.002) across both sexes and correlated with the severity of diabetes,
marked by the presence of diabetes complications, researchers report in the
October issue of the Journal of Pediatrics.
Diabetics with hypertension, retinopathy, or microalbuminuria had
significantly thicker carotid IMT than did subjects who did not have these
complications.
In male but not female diabetic subjects, researchers noted a significant
negative correlation between carotid IMT and HDL cholesterol and a
significant positive correlation between carotid IMT and the LDL/HDL ratio.
"Cardiovascular disease is the leading cause of morbidity and mortality in
people with diabetes, and atherosclerosis is the underlying foundation of
cardiovascular disease," co-author Dr. Wendy J. Mack from the University of
Southern California in Los Angeles noted in comments to Reuters Health.
"Our study shows that atherosclerosis, begins early and that it relates to
abnormalities of lipids and to diabetes complications," she said.
"Providers of diabetes care for children and youth," she added, "need to
begin to monitor lipids and consider interventions according to the
standards of care for diabetes in children to help avert cardiovascular
disease in the future."
J Pediatr 2004;145:452-457.
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