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Artery hardening begins early in diabetes
Artery hardening begins early in diabetes -- Posted by Gumbo on 11-16-04 04:59
Artery hardening begins early in diabetes
Oct 28 (Reuters Health) - There's more evidence that atherosclerosis --
hardening of the arteries -- starts early in young people with type 1
diabetes, underscoring the need to monitor blood pressure and cholesterol
levels in adolescents with the disease.
"Cardiovascular disease is the leading cause of morbidity and mortality in
people with diabetes, and atherosclerosis is the underlying foundation of
cardiovascular disease," Dr. Wendy J. Mack from the University of Southern
California in Los Angeles commented to Reuters Health.
She and her colleagues measured the thickness of the wall of the carotid
artery -- an indicator of sub-clinical atherosclerosis -- in 142 people
ranging in age from 12 to 25 who had type 1 diabetes, and in a comparison
group of 87 age-matched non-diabetic "controls."
The team also measured blood levels of cholesterol and other lipids, blood
pressure, weight in relation to height, and the degree of blood glucose
control in the diabetic subjects.
The carotid wall was significantly thicker on average in diabetic than in
non-diabetic participants across both sexes, the investigators report in the
Journal of Pediatrics.
Diabetics with high blood pressure, retinal damage, or impaired kidney
function had significantly thicker carotid walls than did subjects who did
not have these complications.
In male but not female diabetic subjects, the researchers saw that carotid
wall thickness decreased as levels of HDL ("good") cholesterol increased.
"Our study shows that atherosclerosis begins early and that it relates to
abnormalities of lipids and to diabetes complications," Mack concluded.
"Providers of diabetes care for children and youth," she added, "need to
begin to monitor lipids and consider interventions according to the
standards of care for diabetes in children to help avert cardiovascular
disease in the future."
SOURCE: Journal of Pediatrics, October 2004.
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