---
Preventing Microalbuminuria in Type 2 Diabetes
Preventing Microalbuminuria in Type 2 Diabetes -- Posted by Gumbo on 11-16-04 20:32
Preventing Microalbuminuria in Type 2 Diabetes
on Tuesday, November 09 @ 15:48:09 EST
In subjects with type 2 diabetes and hypertension but with normoalbuminuria,
the use of trandolapril plus verapamil and trandolapril alone decreased the
incidence of microalbuminuria.
The multicenter double-blind, randomized Bergamo Nephrologic Diabetes
Complications Trial (BENEDICT) was designed to assess whether
angiotensin-converting-enzyme inhibitors and non-dihydropyridine
calcium-channel blockers, alone or in combination, prevent microalbuminuria
in subjects with hypertension, type 2 diabetes mellitus, and normal urinary
albumin excretion.
They studied 1204 subjects, who were randomly assigned to receive at least
three years of treatment with trandolapril (at a dose of 2 mg per day) plus
verapamil (sustained-release formulation, 180 mg per day), trandolapril
alone (2 mg per day), verapamil alone (sustained-release formulation, 240 mg
per day), or placebo. The target blood pressure was 120/80 mm Hg. The
primary end point was the development of persistent microalbuminuria
(overnight albumin excretion, >/=20 microg per minute at two consecutive
visits).
The results showed that the primary outcome was reached in 5.7 percent of
the subjects receiving trandolapril plus verapamil, 6.0 percent of the
subjects receiving trandolapril, 11.9 percent of the subjects receiving
verapamil, and 10.0 percent of control subjects receiving placebo. The
estimated acceleration factor (which quantifies the effect of one treatment
relative to another in accelerating or slowing disease progression) adjusted
for predefined baseline characteristics was 0.39 for the comparison between
verapamil plus trandolapril and placebo , 0.47 for the comparison between
trandolapril and placebo , and 0.83 for the comparison between verapamil and
placebo.
Trandolapril plus verapamil and trandolapril alone delayed the onset of
microalbuminuria by factors of 2.6 and 2.1, respectively. Serious adverse
events were similar in all treatment groups.
From the results it was concluded that, in subjects with type 2 diabetes and
hypertension but with normoalbuminuria, the use of trandolapril plus
verapamil and trandolapril alone decreased the incidence of microalbuminuria
to a similar extent. The effect of verapamil alone was similar to that of
placebo.
N Engl J Med. 2004 Oct 31
Related
Discussion:
Flawed Vacuum Cleaners. video clip (1 posts)
by Bjay - Last post on: 02-21-04 23:33
Re Flawed Vacuum Cleaners.
Since first posting this subject we have produce a small Video Clip to
demonstrate just how efficient the Air Recycling Cleaner, is.
See http://www.edginton.info/arc
The original posting said,
The Vacuum Cleaners we use have many major flaws.
1/. They rele... (Read More)
Make at least $5000 per week. (2 posts)
by Nick Colombe - Last post on: 09-16-05 13:19
This system is FREE and it's guaranteed. You can learn to do it. It's easy & simple. It doesn't get any better than that.
This offer will not last long. Normally this E-book would sell for $99.95, but not TODAY! Check this website NOW!
http://www.tradevestor.com/partner/go/878.php
-... (Read More)
Duragesic fentanyl patch overdose (1 posts)
by kr0 - Last post on: 07-27-05 07:07
Apparently there is an issue with the Duragesic fentanyl time release pain
patch releasing a full dose, which can cause an overdose. Janssen
Pharmaceutical Products has issued a recall of a number of the defective
patches. If you go to https://www.lawyersandsettlements.com/case/duragesic
there i... (Read More)
BUY 100mg Viagra Online From a Trusted U.S Pharmacy (1 posts)
by Doctor James Watson - Last post on: 01-26-05 19:29
http://pharmacy.edrugstore.md/z/44/CD1643
Fight Sexual health related Issues with the little Blue Pill. Safely ! Top Quality Pharmacy Online Store,No hidden charges, Free Overnight Delivery.Free Consultations
http://pharmacy.edrugstore.md/z/44/CD1643
---
MAF Anti-Spam ID: 200501252... (Read More)
Top
Discussions From Our Archives
Now I'm puzzled
IMpotence & Walking
Other
Discussion Categories
Diabetes Symptoms
Health Care Policy
Health Care Providers HMO
| 
