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Lipitor little help to diabetics on dialysis
Lipitor little help to diabetics on dialysis -- Posted by Gumbo on 11-19-04 05:17
Lipitor little help to diabetics on dialysis
Nov 02 (Reuters Health) - People with type 2 diabetes who have progressed to
kidney failure don't gain much benefit from treatment with a statin drug
like Lipitor, German researchers have found.
Lipitor did not appear to lower the risk of heart attack or stroke much in
such patients, according to results of a large study presented last week in
St. Louis at the meeting of the American Society of Nephrology.
In the trial, investigators treated a total of 1255 type 2 diabetic patients
who were on hemodialysis with Lipitor or a matching placebo pill for an
average of four years.
Lipitor was very safe and it did lower LDL ("bad") cholesterol an average of
41 percent, Dr. Christoph Wanner from University Clinic in Wuerzburg told
Reuters Health. "This is the good news of the trial," he said.
"The conservative news," he said, is that the reduction in the combination
of cardiac death, non-fatal heart attack and stroke with Lipitor was slight
compared with the rate in the placebo group. "There was an 8 percent risk
reduction with statin therapy, which is not statistically significant."
This was a bit of a surprise, Wanner noted, given recent findings that
Lipitor has significant benefits for people with type 2 diabetes who have
not developed major kidney disease.
The take-home message from the current trial "is to provide statin treatment
to patients with type 2 diabetes during the early stage of disease
progression and not when it's too late," Wanner said.
"Type 2 diabetics who have reached terminal renal failure and are maintained
on chronic hemodialysis have the highest risk of cardiovascular death among
any patient group," Wanner pointed out. "So probably it's too late in the
vascular life of the patient to (start) statin treatment."
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