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Diabetes drug useful for ovary disease
Diabetes drug useful for ovary disease -- Posted by Gumbo on 12-12-04 06:30
Diabetes drug useful for ovary disease
(Reuters Health) - Treatment with the diabetes drug rosiglitazone, which is
marketed under the trade name Avandia, can restore ovulation in obese women
with polycystic ovary syndrome (PCOS), a disease involving high levels of
male hormones resulting in fertility and menstrual problems, new research
shows.
Metformin, another diabetes drug that can restore ovarian function, is
associated with significant gastrointestinal side effects and is not
effective in obese women with PCOS, Drs. Vicken Sepilian and Manubai
Nagamani, from the University of Texas Medical Branch in Galveston, note.
They therefore tested rosiglitazone as an alternative treatment in 12 obese
women with PCOS, according to the report in the Journal of Clinical
Endocrinology and Metabolism. Unlike metformin, rosiglitazone belongs to a
group of drugs called thiazolidinediones, which work by making the body more
sensitive to insulin, the key hormone that lowers blood sugar levels.
Ovulation was restored in 11 of the 12 women, with spontaneous menstruation
occurring within the first 3 months of treatment, the authors note.
Moreover, a dramatic drop in blood levels of the potent male hormone
testosterone occurred. As expected, the patients also experienced an
improvement in their sensitivity to insulin.
Thiazolidinediones, the researchers conclude "may be the ideal treatment for
obese PCOS women with (poor insulin sensitivity) who desire fertility."
However, they note that rosiglitazone should be discontinued if a patient
becomes pregnant.
SOURCE: Journal of Clinical Endocrinology and Metabolism,
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