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New drug may be better than aspirin for diabetics


New drug may be better than aspirin for diabetics -- Posted by Gumbo on 12-13-04 04:37


New drug may be better than aspirin for diabetics
Nov 17 (Reuters Health) - A drug called picotamide appears to be a more
effective blood-thinner than aspirin for people with diabetes, according to
an Italian study.


Previous research has suggested that aspirin may not work as well for
diabetics in preventing vascular events, such as heart attacks or stroke, as
it does for other people.


Dr. Sergio Coccheri, of the University of Bologna, and colleagues tested
picotamide -- which has a double-action anti-platelet effect -- against
aspirin in 1200 patients ages 40 to 75 with a history of type 2 diabetes and
peripheral arterial disease.


The results of their study, published in the European Heart Journal, show
that over an average period of 2 years, there were 17 deaths in the
picotamide group and 31 in the aspirin group. The 45 percent difference in
mortality risk was statistically significant, Coccheri's team reports.


However, when deaths were combined with non-fatal heart attacks and strokes,
as well as major amputations, there was no difference between the two
groups.


Gastric discomfort occurred in 11 percent of the picotamide group versus 18
percent of those on aspirin, suggesting that picotamide's "tolerability
profile was somewhat advantageous over that of aspirin," the authors write.


In an accompanying editorial, however, Drs. Paolo Gresele and Rino
Migliacci, at the University of Perugia, point out that the study was
conducted before the widespread use of drugs like ACE inhibitors and anti-
cholesterol agents -- which may improve outcomes that overshadow
picotamide's benefits.


Moreover, they add, additional study will be needed to see if picotamide
performs better than aspirin combined with Plavix.


SOURCE: European Heart Journal, October 2004.




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