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Risk Of Chronic Heart Failure With Insulin Sensitizers
Risk Of Chronic Heart Failure With Insulin Sensitizers -- Posted by Gumbo on 12-24-04 06:11
Risk Of Chronic Heart Failure With Insulin Sensitizers
More patients were diagnosed with chronic heart failure after 6 months of
starting rosiglitazone.
A group of researchers led by Dr Jennifer Marceille of the Edward Hines Jr.
Veterans Affairs Medical Center in Hines, USA, evaluated the relationship
between rosiglitazone therapy and chronic heart failure in patients with
type 2 diabetes. A total of 139 patients were identified who were receiving
insulin therapy and had rosiglitazone added to their therapy. Medical
records were reviewed for 6 months before and 6 months after initiation of
rosiglitazone treatment.
The researchers found that chronic heart failure was diagnosed in 25% of
patients before starting rosiglitazone and in 30% after starting
rosiglitazone. Medical intervention for chronic heart failure was needed in
36% of patients after starting rosiglitazone, compared with 14% before
rosiglitazone (p<0.0001). Of the patients requiring medical intervention
after starting rosiglitazone, 66% had not needed any intervention before
starting rosiglitazone. The most common symptom was lower-extremity oedema,
which occurred in 18% of patients before starting rosiglitazone and in 36%
after starting rosiglitazone (p<0.0001).
The researchers concluded that more patients were diagnosed with chronic
heart failure during the 6 months after starting rosiglitazone than in the 6
months before starting rosiglitazone in insulin-treated patients with type 2
diabetes.
Pharmacotherapy 2004;24:1317-22
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