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--- Sleep-Disordered Breathing Associated with Insulin Resistance
Well, I'll be darned Gumbo. Thanks for this article. I suffer from severe sleep apea. I have been gaining weight over the last 9 years but have not done an updated sleep study until this month. (old pressures was 12/7 -- new pressures 17/10). Coincidentally, my doctor just diagnosed me with Type 2 diabetes. I wonder if, now that my pressures are adjusted right now, if my IR will return to closer to normal over the next few years? It'll be interesting to see. Gumbo wrote: > Sleep-Disordered Breathing Associated with Insulin Resistance > > > Results from the Sleep Heart Health Study demonstrate an association between > Sleep-disordered breathing and insulin resistance. > > According to recent research published in the American Journal of > Epidemiology, "Clinic-based studies suggest that sleep-disordered breathing > (SDB) is associated with glucose intolerance and insulin resistance. > However, in the available studies, researchers have not rigorously > controlled for confounding variables to assess the independent relation > between SDB and impaired glucose metabolism. The objective of this study was > to determine whether SDB was associated with glucose intolerance and insulin > resistance among community-dwelling subjects (n=2,656) participating in the > Sleep Heart Health Study (1994-1999)." > > "SDB was characterized with the respiratory disturbance index and > measurements of oxygen saturation during sleep," said Naresh M. Punjabi at > Johns Hopkins University and fellow members of the Sleep Heart Health Study > Investigators. "Fasting and 2-hour glucose levels measured during an oral > glucose tolerance test were used to assess glycemic status. Relative to > subjects with a respiratory disturbance index of less than 5.0 events/hour > (the reference category), subjects with mild SDB (5.0-14.9 events/hour) and > moderate to severe SDB (greater than or equal to 15 events/hour) had > adjusted odds ratios of 1.27 (95% confidence interval: 0.98, 1.64) and 1.46 > (95% confidence interval: 1.09, 1.97), respectively, for fasting glucose > intolerance (ptrend<0.01)." > > "Sleep-related hypoxemia was also associated with glucose intolerance > independently of age, gender, body mass index, and waist circumference," > reported the researchers. "The results of this study suggest that > sleep-disordered breathing is independently associated with glucose > intolerance and insulin resistance and may lead to type 2 diabetes > mellitus." > > Punjabi and colleagues published their study in the American Journal of > Epidemiology (Sleep-disordered breathing, glucose intolerance, and insulin > resistance - The Sleep Heart Health Study. Amer J Epidemiol, > 2004;160(6):521-530). > > For additional information, contact Naresh M. Punjabi, Johns Hopkins Asthma > and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. > E-mail: npunjabi@jhmi.edu. > > The publisher's contact information for the American Journal of Epidemiology > is: Oxford University Press Inc., Journals Department, 2001 Evans Road, > Cary, NC 27513, USA. > > The information in this article comes under the major subject areas of > Insulin Resistance, Sleep Disorder, Glucose Intolerance, Diabetes > Complications, Sleep Apnea Syndromes, and Endocrinology. This article was > prepared by Biotech Week editors from staff and other reports
D. Allgrove wrote: > Well, I'll be darned Gumbo. Thanks for this article. I suffer from > severe sleep apea. I have been gaining weight over the last 9 years but > have not done an updated sleep study until this month. (old pressures > was 12/7 -- new pressures 17/10). Coincidentally, my doctor just > diagnosed me with Type 2 diabetes. I wonder if, now that my pressures > are adjusted right now, if my IR will return to closer to normal over > the next few years? It'll be interesting to see. > > Gumbo wrote: > >> Sleep-Disordered Breathing Associated with Insulin Resistance >> >> >> Results from the Sleep Heart Health Study demonstrate an association >> between Sleep-disordered breathing and insulin resistance. >> >> According to recent research published in the American Journal of >> Epidemiology, "Clinic-based studies suggest that sleep-disordered >> breathing (SDB) is associated with glucose intolerance and insulin >> resistance. However, in the available studies, researchers have not >> rigorously controlled for confounding variables to assess the >> independent relation between SDB and impaired glucose metabolism. The >> objective of this study was to determine whether SDB was associated >> with glucose intolerance and insulin resistance among >> community-dwelling subjects (n=2,656) participating in the Sleep Heart >> Health Study (1994-1999)." >> >> "SDB was characterized with the respiratory disturbance index and >> measurements of oxygen saturation during sleep," said Naresh M. >> Punjabi at Johns Hopkins University and fellow members of the Sleep >> Heart Health Study Investigators. "Fasting and 2-hour glucose levels >> measured during an oral glucose tolerance test were used to assess >> glycemic status. Relative to subjects with a respiratory disturbance >> index of less than 5.0 events/hour (the reference category), subjects >> with mild SDB (5.0-14.9 events/hour) and moderate to severe SDB >> (greater than or equal to 15 events/hour) had adjusted odds ratios of >> 1.27 (95% confidence interval: 0.98, 1.64) and 1.46 (95% confidence >> interval: 1.09, 1.97), respectively, for fasting glucose intolerance >> (ptrend<0.01)." >> >> "Sleep-related hypoxemia was also associated with glucose intolerance >> independently of age, gender, body mass index, and waist >> circumference," reported the researchers. "The results of this study >> suggest that sleep-disordered breathing is independently associated >> with glucose intolerance and insulin resistance and may lead to type 2 >> diabetes mellitus." >> >> Punjabi and colleagues published their study in the American Journal >> of Epidemiology (Sleep-disordered breathing, glucose intolerance, and >> insulin resistance - The Sleep Heart Health Study. Amer J Epidemiol, >> 2004;160(6):521-530). >> >> For additional information, contact Naresh M. Punjabi, Johns Hopkins >> Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD >> 21224, USA. E-mail: npunjabi@jhmi.edu. >> >> The publisher's contact information for the American Journal of >> Epidemiology is: Oxford University Press Inc., Journals Department, >> 2001 Evans Road, Cary, NC 27513, USA. >> >> The information in this article comes under the major subject areas of >> Insulin Resistance, Sleep Disorder, Glucose Intolerance, Diabetes >> Complications, Sleep Apnea Syndromes, and Endocrinology. This article >> was prepared by Biotech Week editors from staff and other reports Very interesting this... I've just had a sleep apnoeia test as I have been suffering with excessive daytime sleepyness for some time. I put it down to having a 19" collar size but a relationship to my diabetes... worth reading up on! Martin. (T2 since 1998, Novorapid/Levemir/Metformin) Related Discussion: How to test your blood sugar (1 posts) EASY PHONESEX - call this 800 number and talk to someone now 9189 (1 posts) Re: FREE Info on HEAlth and WEAlth (1 posts) Looking for a second income, or to change your life forever? (1 posts) Top Discussions From Our Archives We would like to invite you to join the Natural Health Forum! [Fwd: Im trying this for gout because NOTHHING else works] Other Discussion Categories Diabetes Symptoms Health Care Policy Health Care Providers HMO Arthritis Symptoms
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