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Intranasal insulin reduces body fat in men but not in women.
Intranasal insulin reduces body fat in men but not in women. -- Posted by Gumbo on 02-02-05 06:30
Intranasal insulin reduces body fat in men but not in women.
According to recent research from Germany, "Insulin acts in the central
nervous system to reduce food intake and body weight and is considered a
major adiposity signal. After intranasal administration, insulin enters the
cerebrospinal fluid compartment and alters brain functions in the absence of
substantial absorption into the blood stream. Here we report the effects of
8 weeks of intranasal administration of insulin (4 x 40 IU/day) or placebo
to two groups of healthy human subjects (12 men and 8 women in each group)."
"The insulin-treated men lost 1.28 kg body weight and 1.38 kg of body fat,
and their waist circumference decreased by 1.63 cm," reported Manfred
Hallschmid and colleagues at the University of Lubeck. "Plasma leptin levels
dropped by an average of 27%.In contrast, the insulin-treated women did not
lose body fat and gained 1.04 kg body weight due to a rise in extracellular
water."
The researchers concluded, "Our results provide a strong, first confirmation
in humans that insulin acts as a negative feedback signal in the regulation
of adiposity and point to a differential sensitivity to the catabolic
effects of insulin based on sex."
Hallschmid and associates published their study in Diabetes (Intranasal
insulin reduces body fat in men but not in women. Diabetes,
2004;53(11):3024-3029).
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