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Use of Diabetes Drugs Linked to Risk of Heart Failure
Use of Diabetes Drugs Linked to Risk of Heart Failure -- Posted by Gumbo on 02-02-05 06:33
Use of Diabetes Drugs Linked to Risk of Heart Failure
The use of drugs to treat type 2 diabetes appears to be associated with an
increased risk of heart failure, according to a study published in the
January issue of Diabetes Care. Several previous studies reported an
increased risk of heart failure associated with the use of insulin or
glitazones, while another study found no such risk, authors of the study
noted. Researchers conducted a retrospective cohort study of 25,690 newly
diagnosed diabetes patients registered in the U.K. General Practice Research
Database from 1988-1999. Person-time drug exposures were categorized to mono
therapies in insulin, sulfonylureas (SUs), metformins and other oral
hypoglycemic agents (acarbose or guar gum). Patients receiving combination
therapy or triple therapy, with or without insulin, also were included. The
study covered 43,390 drug exposure intervals (defined as the duration from
the onset of one drug exposure to the onset of the next exposure or until
censored or heart failure). Of the 25,690 participants, 1,409 developed
heart failure. The mean follow-up period was 2.5 years .Heart failure was
most frequent in patients receiving SU monotherapy. When the researchers
adjusted for duration of diabetes, timing and order of treatments received
and known risk factors for heart failure, no differential effects were found
among type-specific therapies. Patients who began therapy within the first
year following diagnosis of diabetes had a 4.75-fold higher risk of heart
failure than those who did not begin therapy in the first year."This risk
does not persist beyond the first year after diagnosis of diabetes and does
not appear to differ among the types of drug therapy examined," the study's
authors concluded. "This observation suggests that the severity of diabetes
or the preclinical duration of diabetes and the need for drug therapy, and
not the therapy itself, is an explanation for heart failure in many patients
with type 2 diabetes."
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