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Waist Circumference Linked to Blood Pressure, Insulin Sensitivity
Waist Circumference Linked to Blood Pressure, Insulin Sensitivity -- Posted by Gumbo on 03-25-05 04:40
Waist Circumference Linked to Blood Pressure, Insulin Sensitivity
By Will Boggs, MD
NEW YORK (Reuters Health) - Waist circumference may account for differences
in blood pressure and insulin sensitivity, according to a report in the
March issue of Hypertension.
Abdominal obesity, reflected by increased waist circumference, is often
accompanied by features of the metabolic syndrome, the authors explain, but
the relative contributions of abdominal obesity versus hyperinsulinemia to
high blood pressure are poorly understood.
Dr. Paul Poirier from Laval Hospital Research Center, Sainte-Foy, Quebec,
Canada and colleagues investigated the contributions of excess adiposity
(measured by BMI), abdominal fat accumulation (measured by waist
circumference), fasting insulin level, and insulin sensitivity to the
variation of resting blood pressure in 907 men and 937 women.
All four variables were significantly correlated with systolic blood
pressure in men and women and with diastolic blood pressure in women, the
authors report. Only BMI and waist circumference correlated significantly
with diastolic blood pressure in men.
In multivariate analyses, waist circumference was the best independent
variable in explaining the variance of either diastolic or systolic blood
pressure.
When men and women were classified into tertiles of fasting insulin and
waist circumference, the researchers note, there was no association between
variation in insulin and blood pressure once the variation in waist
circumference was taken into account.
"Results of the present study suggest that the well-documented association
between obesity, fasting insulin, insulin sensitivity, and blood pressure
may largely, if not entirely, be explained by phenomena related to the
concomitant variation in the amount of abdominal fat, as estimated by a
simple clinical parameter: waist circumference," the investigators write.
"Not all obese individuals are the same," Dr. Poirier told Reuters Health.
"We must target the obese at risk, which are the ones with abdominal
obesity, low HDL and triglycerides above 1.7 mmol/L."
"We are looking at other populations to see if the conclusions are the
same," he added.
"We should not neglect the possibility that visceral fat accumulation and
hypertension may be parallel consequences of one or more common progenitor
abnormalities," writes Dr. Ele Ferrannini from University of Pisa School of
Medicine, Pisa, Italy in a related commentary. "Clearly, there is much
research to perform before we fully understand how traveling along a wide
circumference gets us to high blood pressure."
Hypertension 2005;45:347-348,363-367.
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