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Obesity a Risk Factor for acid reflux disease & esophageal erosion
Obesity a Risk Factor for acid reflux disease & esophageal erosion -- Posted by Sweet Zombie Jesus! on 06-03-05 09:52
INTRODUCTION: An association between obesity and GERD symptoms has been
reported; however, study results have been inconsistent and it is not
known whether an association persists after adjusting for other known
GERD risk factors.
METHODS: We carried out a cross-sectional study to determine the
prevalence and risk factors of GERD in volunteers (VA employees).
Participants completed a Gastroesophageal Reflux Questionnaire, the
Block 98 Food Frequency Questionnaire, provided height and weight
information, and were invited for upper endoscopy with biopsies.
Associations of body mass index (BMI) with GERD symptoms and erosive
esophagitis were examined separately in multiple logistic regression
analyses adjusting for age, sex, race, GERD symptoms, dietary intake,
education level, family history of GERD, H. pylori infection, and the
presence and distribution of gastritis.
RESULTS: Four hundred and fifty-three persons (mean age 44 yr, 70%
women and 43% black) provided complete information on heartburn,
regurgitation, and BMI (50% of 915 who received questionnaires). Of the
196 who underwent endoscopy, 44 (22%) had esophageal erosions and 118
(26%) reported at least weekly heartburn or regurgitation. A
dose-response relationship between frequency of heartburn or
regurgitation and higher BMI was observed. Compared to participants
without weekly symptoms, a significantly larger proportion of the 118
with these symptoms were either overweight (BMI 25-30) (35%vs 32%) or
obese (BMI >30) (39%vs 26%), p for linear trend 0.004. Relative to
those with no esophageal erosions, those with erosions were more likely
to be overweight (39%vs 26%) or obese (41%vs 32%), p= 0.04. Obese
participants were 2.5 times as likely as those with normal BMI (<25) to
have reflux symptoms or esophageal erosions. The association between
BMI and GERD symptoms persisted in direction and magnitude after
adjustment for potential confounders.
CONCLUSIONS: Overweight and obesity are strong independent risk factor
of GERD symptoms and esophageal erosions. The amount or composition of
dietary intake does not appear to be a likely explanation for these
findings.
(Am J Gastroenterol 2005;100:1-8).Am J Gastroenterol. 2005
Jun;100(6):1243-50. Obesity Is an Independent Risk Factor for GERD
Symptoms and Erosive Esophagitis.
El-Serag HB, Graham DY, Satia JA, Rabeneck L. Sections of
Gastroenterology and Health Services Research at the Houston Department
of Veterans Affairs Medical Center and Baylor College of Medicine,
Houston, Texas.
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