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Sibutramine may control binge-eating in obese individuals
Sibutramine may control binge-eating in obese individuals -- Posted by The Mongolian Death Worm on 06-03-05 10:12
BACKGROUND: Binge-eating disorder was recently included in Appendix B
of the Diagnostic and Statistical Manual of Mental Disorders, Fourth
Edition (DSM-IV). Binge-eating disorder is a common diagnosis among
patients who seek treatment for obesity. There are scant data about the
efficacy of the novel antiobesity agents for binge-eating disorder. The
objective of this article is to present data from an open-label study
of the efficacy and tolerability of sibutramine in a group of obese
binge eaters.
METHOD: Ten obese patients with DSM-IV binge-eating disorder and no
medical comorbidity were consecutively selected from individuals
seeking treatment for obesity in our clinic. Treatment with
sibutramine, 15 mg/day, was administered for 12 weeks. The number of
days with binge episodes per week, the number of binge episodes per
week, the Binge Eating Scale (BES), the Beck Depression Inventory, and
body weight evaluation were employed for outcome assessment.
RESULTS: Seven patients completed the trial. They showed a complete
resolution of binge-eating disorder with no binge-eating episodes at
the end of the treatment. The mean +/- SD number of days with binge
episodes per week changed significantly from 5.2 +/- 1.8 at baseline to
0.8 +/- 1.9 at the end of the study (p < .001), and the mean BES score
fell from 31.2 +/- 6.2 to 15.2 +/- 8.2. There was a reduction of body
weight (mean = 4.0 kg [8.9 lb]) from baseline to the end of the study.
No serious adverse effects were observed.
CONCLUSION: Sibutramine might be an effective and well-tolerated agent
in the treatment of binge-eating disorder in obese patients.
J Clin Psychiatry. 2002 Jan;63(1):28-30. An open-label trial of
sibutramine in obese patients with binge-eating disorder. Appolinario
JC, Godoy-Matos A, Fontenelle LF, Carraro L, Cabral M, Vieira A,
Coutinho W.Obesity and Eating Disorders Group, Institute of Psychiatry,
Federal University of Rio de Janeiro, Brazil. appolinario@biohard.com.br
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