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Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers.
Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers. -- Posted by tigerlilly@privacy.net.org.com on 06-07-05 15:26
Cefotiam disposition in markedly obese athlete patients, Japanese sumo
wrestlers.
K Chiba, M Tsuchiya, J Kato, K Ochi, Z Kawa, and T Ishizaki
Division of Clinical Pharmacology, National Medical Center, Tokyo, Japan.
Abstract
Markedly obese athletes like Japanese sumo wrestlers may frequently suffer
various traumas which result in the prophylaxis or treatment of posttraumatic
infection with antibiotics. However, appropriate dosage regimens in this group
of patients have not been fully known for many antibiotics. Therefore, we
studied the kinetic disposition of cefotiam, a parenteral, broad-spectrum
cephalosporin with activity against gram-positive and -negative bacteria, after
an intravenous dose (2 g) infused over 30 min into 15 sumo wrestler patients
with an excess body weight (130 to 220% of ideal body weight) and 10 control
patients with a normal weight (90 to 102% of ideal body weight). Mean (+/-
standard deviation) clearance and steady-state volume of distribution were
significantly greater in the sumo wrestler than in the control group (38.3 +/-
9.4 versus 23.5 +/- 6.0 liters/h, P less than 0.001, and 30.2 +/- 8.0 versus
17.9 +/- 6.1 liters, P less than 0.001). Mean elimination half-life was slightly
but significantly longer in the sumo wrestler than in the control group (0.91
+/- 0.14 versus 0.74 +/- 0.20 h, P less than 0.05). However, mean residence time
did not differ between the two groups (0.79 +/- 0.10 versus 0.75 +/- 0.14 h).
The statistical differences in clearance and volume of distribution between the
two groups disappeared when these kinetic parameters were corrected for body
surface area, but not for total body weight or ideal body weight. The results
suggest that the dosage calculation of cefotiam, a hydrophilic antibiotic,
should be made on the basis of body surface area in morbidly obese athlete or
sumo wrestler patients. However, whether this recommendation should extend to
other nonathlete obese subjects remains to be determined.
Full textFull text is available as a scanned copy of the original print version.
Get a printable copy (PDF file) of the complete article (859K), or see the
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1189
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1191
1192ReferencesReference citations from this article are linked, where possible,
to the corresponding full text in PubMed Central (PMC) or a PubMed citation. The
list below may not include every reference from the original article.Abernethy
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